Endoteliální hemostatické markery u jedinců z rodin s familiární kombinovanou hyperlipidemií

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00006144" target="_blank" >RIV/61989592:15110/08:00006144 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Endothelial haemostatic markers in members of families with familial combined hyperlipidemia

Popis výsledku v původním jazyce

Introduction: The aim of this study was to evaluate the plasma levels of endothelial haemostatic markers - von Willebrand factor (sWF), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA) and soluble thrombomodulin (sTM) - in asymptomatic, nonsmoking members of families with familial combined hyperlipidemia (FCH). We investigated the association between these factors and the intima-media thickness (IMT) of the common carotid artery, selected risk factors of atherosclerosis andmarkers of insulin resistance. Methods. 82 members of 29 FCH families were divided into two groups: HL (probands and hyperlipidemic first - degree relatives, n=47) and NL (normolipidemic first-degree relatives, n=35). The control groups C-HL (n=20) andC-NL (n=20) consisted of sex- and age-matched healthy individuals. IMT was measured by ultrasound at a far wall of both common carotid arteries. Results: Compared with healthy controls, hyperlipidemic subjects had significantly higher lev

Název v anglickém jazyce

Endothelial haemostatic markers in members of families with familial combined hyperlipidemia

Popis výsledku anglicky

Introduction: The aim of this study was to evaluate the plasma levels of endothelial haemostatic markers - von Willebrand factor (sWF), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (t-PA) and soluble thrombomodulin (sTM) - in asymptomatic, nonsmoking members of families with familial combined hyperlipidemia (FCH). We investigated the association between these factors and the intima-media thickness (IMT) of the common carotid artery, selected risk factors of atherosclerosis andmarkers of insulin resistance. Methods. 82 members of 29 FCH families were divided into two groups: HL (probands and hyperlipidemic first - degree relatives, n=47) and NL (normolipidemic first-degree relatives, n=35). The control groups C-HL (n=20) andC-NL (n=20) consisted of sex- and age-matched healthy individuals. IMT was measured by ultrasound at a far wall of both common carotid arteries. Results: Compared with healthy controls, hyperlipidemic subjects had significantly higher lev

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NR9068" target="_blank" >NR9068: Klasifikace dyslipidemií založená na koncentraci apolipoproteinu B a triglyceridů. Asociace dyslipidemických fenotypů s ukazateli inzulínové rezistence, zánětu, trombózy, subklinické a klinické aterosklerózy a s vybranými DNA markery.</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Thrombosis Research

ISSN

0049-3848

e-ISSN

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Svazek periodika

123

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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