Cévní reaktivita brachiální tepny u jedinců z rodin s familiární kombinovanou hyperlipidémií a její vztah k tloušťce intima-media společné karotidy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F06%3A00003167" target="_blank" >RIV/61989592:15110/06:00003167 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

BRACHIAL ENDOTHELIAL FUNCTION IN SUBJECTS WITH FAMILIAL COMBINED HYPERLIPIDEMIA AND ITS RELATIONSHIPS TO CAROTID ARTERY INTIMA-MEDIA THICKNESS

Popis výsledku v původním jazyce

Aim: The aim of this study was to quantify the flow mediated dilatation of brachial artery (FMD) in asymptomatic members of families with familial combined hyperlipidemia (FCH) and to determine the relation between FMD and risk factors accompanying FCH.We also investigated the association between FMD and the intima-media thickness (IMT) of the common carotid artery. Methods: 82 members of 29 FCH families were divided into two groups: HL (probands and hyperlipidemic first-degree relatives, n=47) and NL(normolipidemic first-degree relatives, n=35). The control groups - C-HL (n=20) and C-NL (n=20) - consisted of sex- and age-matched healthy individuals. FMD was assessed in the brachial artery by measuring the change in brachial artery diameter in response to reactive hyperemia. Results: Both hyperlipidemic subjects and their normolipidemic relatives had significantly lower FMD (3.4&#61617;3.0% vs 6.3&#61617;2.8%, p<0.001, 5.2&#61617;2.3% vs 7.8&#61617;2.8%, p<0.01 respectively)

Název v anglickém jazyce

BRACHIAL ENDOTHELIAL FUNCTION IN SUBJECTS WITH FAMILIAL COMBINED HYPERLIPIDEMIA AND ITS RELATIONSHIPS TO CAROTID ARTERY INTIMA-MEDIA THICKNESS

Popis výsledku anglicky

Aim: The aim of this study was to quantify the flow mediated dilatation of brachial artery (FMD) in asymptomatic members of families with familial combined hyperlipidemia (FCH) and to determine the relation between FMD and risk factors accompanying FCH.We also investigated the association between FMD and the intima-media thickness (IMT) of the common carotid artery. Methods: 82 members of 29 FCH families were divided into two groups: HL (probands and hyperlipidemic first-degree relatives, n=47) and NL(normolipidemic first-degree relatives, n=35). The control groups - C-HL (n=20) and C-NL (n=20) - consisted of sex- and age-matched healthy individuals. FMD was assessed in the brachial artery by measuring the change in brachial artery diameter in response to reactive hyperemia. Results: Both hyperlipidemic subjects and their normolipidemic relatives had significantly lower FMD (3.4&#61617;3.0% vs 6.3&#61617;2.8%, p<0.001, 5.2&#61617;2.3% vs 7.8&#61617;2.8%, p<0.01 respectively)

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NR9068" target="_blank" >NR9068: Klasifikace dyslipidemií založená na koncentraci apolipoproteinu B a triglyceridů. Asociace dyslipidemických fenotypů s ukazateli inzulínové rezistence, zánětu, trombózy, subklinické a klinické aterosklerózy a s vybranými DNA markery.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Angiology

ISSN

0392-9590

e-ISSN

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Svazek periodika

25

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

9

Strana od-do

418-426

Kód UT WoS článku

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EID výsledku v databázi Scopus

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