Genetic variation in key molecules of the Th-17 immune response is not associated with risk for prosthetic joint infection in a Czech population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33138726" target="_blank" >RIV/61989592:15110/12:33138726 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.5507/bp.2012.023" target="_blank" >http://dx.doi.org/10.5507/bp.2012.023</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2012.023" target="_blank" >10.5507/bp.2012.023</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Genetic variation in key molecules of the Th-17 immune response is not associated with risk for prosthetic joint infection in a Czech population

Popis výsledku v původním jazyce

Background and aims. Prosthetic Joint Infection (PJI) is a serious complication of Total Joint Arthroplasty (TJA). The Th-17 immune response characterised by IL (interleukin)-17A, IL-17F, IL-23, chemotactic cytokines and their receptors, plays a prominent role in the immune response to invading bacteria. In addition, high expression of IL-17A has been reported in PJI. The aim of this study was to investigate whether genetic variation in the key molecules of the Th-17 immune response can affect the riskfor PJI. Methods: Altogether ten Single Nucleotide Polymorphisms (SNPs) of IL17A (rs2275913), IL17F (rs763780), IL4 (rs2243250), IL12A (rs583911), IL12B (rs3212227 and (rs17860508), IL23R (rs7517847), CXCL1 (rs4074), CXCL5 (rs425535) and CXCR2 (rs2230054) genes were genotyped by PCR with sequence specific primers (SSP) in 98 patients with PJI and two kontrol groups 1) an aseptic TJA control (253 patients with TJA that did not develop PJI at least 6 yrs. after the surgery) and 2) a popula

Název v anglickém jazyce

Genetic variation in key molecules of the Th-17 immune response is not associated with risk for prosthetic joint infection in a Czech population

Popis výsledku anglicky

Background and aims. Prosthetic Joint Infection (PJI) is a serious complication of Total Joint Arthroplasty (TJA). The Th-17 immune response characterised by IL (interleukin)-17A, IL-17F, IL-23, chemotactic cytokines and their receptors, plays a prominent role in the immune response to invading bacteria. In addition, high expression of IL-17A has been reported in PJI. The aim of this study was to investigate whether genetic variation in the key molecules of the Th-17 immune response can affect the riskfor PJI. Methods: Altogether ten Single Nucleotide Polymorphisms (SNPs) of IL17A (rs2275913), IL17F (rs763780), IL4 (rs2243250), IL12A (rs583911), IL12B (rs3212227 and (rs17860508), IL23R (rs7517847), CXCL1 (rs4074), CXCL5 (rs425535) and CXCR2 (rs2230054) genes were genotyped by PCR with sequence specific primers (SSP) in 98 patients with PJI and two kontrol groups 1) an aseptic TJA control (253 patients with TJA that did not develop PJI at least 6 yrs. after the surgery) and 2) a popula

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

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Svazek periodika

156

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

248-252

Kód UT WoS článku

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EID výsledku v databázi Scopus

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