Prior Use of Antiplatelet Therapy Can Be Associated with a Higher Chance for Early Recanalization of the Occluded Middle Cerebral Artery in Acute Stroke Patients Treated with Intravenous Thrombolysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33140541" target="_blank" >RIV/61989592:15110/12:33140541 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/12:#0000391 RIV/00843989:_____/12:00102129

Výsledek na webu

<a href="http://dx.doi.org/10.1159/000333064" target="_blank" >http://dx.doi.org/10.1159/000333064</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000333064" target="_blank" >10.1159/000333064</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prior Use of Antiplatelet Therapy Can Be Associated with a Higher Chance for Early Recanalization of the Occluded Middle Cerebral Artery in Acute Stroke Patients Treated with Intravenous Thrombolysis

Popis výsledku v původním jazyce

Background:The early recanalization (ER) of an occluded cerebral artery is important for clinical improvement in acute ischemic stroke. The aim of the study was to assess the possible association between the prior use of antiplatelets (AP) and ER of occluded middle cerebral artery (MCA) after intravenous thrombolysis (IVT).Results: Fifty-six patients (28 males, mean age: 69.8 +/- 9.8 years) used AP and 90 patients were AP naive (51 males, mean age: 65.8 +/- 12.5 years). Prior AP use was associated witha higher rate of early MCA recanalization (53.6 vs. 29.5% in AP naive, p = 0.007) and was shown as a predictor of ER (OR: 2.30, 95% CI: 1.14-4.65; p = 0.020) in unadjusted analysis. No difference was found in the occurrence of SICH. Conclusion: Prior useof AP was associated with a higher rate of ER of occluded MCA, but with no increase of SICH after IVT.

Název v anglickém jazyce

Prior Use of Antiplatelet Therapy Can Be Associated with a Higher Chance for Early Recanalization of the Occluded Middle Cerebral Artery in Acute Stroke Patients Treated with Intravenous Thrombolysis

Popis výsledku anglicky

Background:The early recanalization (ER) of an occluded cerebral artery is important for clinical improvement in acute ischemic stroke. The aim of the study was to assess the possible association between the prior use of antiplatelets (AP) and ER of occluded middle cerebral artery (MCA) after intravenous thrombolysis (IVT).Results: Fifty-six patients (28 males, mean age: 69.8 +/- 9.8 years) used AP and 90 patients were AP naive (51 males, mean age: 65.8 +/- 12.5 years). Prior AP use was associated witha higher rate of early MCA recanalization (53.6 vs. 29.5% in AP naive, p = 0.007) and was shown as a predictor of ER (OR: 2.30, 95% CI: 1.14-4.65; p = 0.020) in unadjusted analysis. No difference was found in the occurrence of SICH. Conclusion: Prior useof AP was associated with a higher rate of ER of occluded MCA, but with no increase of SICH after IVT.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Neurology

ISSN

0014-3022

e-ISSN

—

Svazek periodika

67

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

5

Strana od-do

52-56

Kód UT WoS článku

000299719000010

EID výsledku v databázi Scopus

—