Effects of oral administration of Lonicera caerulea berries on UVB-induced damage in SKH-1 mice. A pilot study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33144121" target="_blank" >RIV/61989592:15110/13:33144121 - isvavai.cz</a>

Výsledek na webu

<a href="http://pubs.rsc.org/en/content/articlelanding/2013/pp/c3pp50120e#!divAbstract" target="_blank" >http://pubs.rsc.org/en/content/articlelanding/2013/pp/c3pp50120e#!divAbstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c3pp50120e" target="_blank" >10.1039/c3pp50120e</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of oral administration of Lonicera caerulea berries on UVB-induced damage in SKH-1 mice. A pilot study

Popis výsledku v původním jazyce

Solar ultraviolet radiation is a major environmental factor that has serious adverse effects on the structure and function of the skin. Although the UVB waveband (295-315 nm) represents only 5-10% of incoming UV light, it is very damaging to the skin. The aim of this study was to investigate the effect of Lonicera caerulea berries on UVB-induced damage to SKH-1 hairless mice. Mice were fed a L. caerulea berry-enriched diet (10%, w/w) for 14 days before a single UVB (1000 mJ cm(-2)) treatment. Effects onhealth status, antioxidant enzyme activity and expression, and DNA damage were evaluated. The bioavailability of L. caerulea phenolic components was also assessed. We found that feeding with L. caerulea berries prevented a decrease in catalase activityand stimulated NADPH quinone oxidoreductase-1, heme oxygenase-1, and gamma-glutamylcysteine synthetase catalytic and modulatory subunit expression in UVB exposed mice. Administration of the L. caerulea berry-enriched diet led to an increa

Název v anglickém jazyce

Effects of oral administration of Lonicera caerulea berries on UVB-induced damage in SKH-1 mice. A pilot study

Popis výsledku anglicky

Solar ultraviolet radiation is a major environmental factor that has serious adverse effects on the structure and function of the skin. Although the UVB waveband (295-315 nm) represents only 5-10% of incoming UV light, it is very damaging to the skin. The aim of this study was to investigate the effect of Lonicera caerulea berries on UVB-induced damage to SKH-1 hairless mice. Mice were fed a L. caerulea berry-enriched diet (10%, w/w) for 14 days before a single UVB (1000 mJ cm(-2)) treatment. Effects onhealth status, antioxidant enzyme activity and expression, and DNA damage were evaluated. The bioavailability of L. caerulea phenolic components was also assessed. We found that feeding with L. caerulea berries prevented a decrease in catalase activityand stimulated NADPH quinone oxidoreductase-1, heme oxygenase-1, and gamma-glutamylcysteine synthetase catalytic and modulatory subunit expression in UVB exposed mice. Administration of the L. caerulea berry-enriched diet led to an increa

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GP303%2F07%2FP314" target="_blank" >GP303/07/P314: Fotoprotektivní účinky přírodních látek na modelech in vitro a in vivo</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Photochemical and Photobiological Sciences

ISSN

1474-905X

e-ISSN

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Svazek periodika

12

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

1830-1840

Kód UT WoS článku

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EID výsledku v databázi Scopus

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