Immunogenetics of Sarcoidosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33144912" target="_blank" >RIV/61989592:15110/13:33144912 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Immunogenetics of Sarcoidosis

Popis výsledku v původním jazyce

Sarcoidosis is a multi-facets disease. Along with environment, the role of genetic component in this immune-mediated granulomatous disorder is undisputable, irrespective of the tissue/ organ involved (lung, eyes, heart, etc.). Due to undefined etiology of this complex disorder, it has remained as challenge to control the disease progression. Further, identification of prognostic genetic maker for this disease at functional as well as non-functional level has remained intriguing. To understand the sarcoidosis susceptibility at genetic level, several molecular approaches, such as meta-analysis of GWAS, significant association of coding and rare variants, fine mapping of susceptible loci, gene networking and their associated mechanism, copy number variations, single nucleotide polymorphisms in miRNAs (mirSNPs) and epigenetic changes in case control studies across cohorts of different ethnic groups would reveal a better insight.

Název v anglickém jazyce

Immunogenetics of Sarcoidosis

Popis výsledku anglicky

Sarcoidosis is a multi-facets disease. Along with environment, the role of genetic component in this immune-mediated granulomatous disorder is undisputable, irrespective of the tissue/ organ involved (lung, eyes, heart, etc.). Due to undefined etiology of this complex disorder, it has remained as challenge to control the disease progression. Further, identification of prognostic genetic maker for this disease at functional as well as non-functional level has remained intriguing. To understand the sarcoidosis susceptibility at genetic level, several molecular approaches, such as meta-analysis of GWAS, significant association of coding and rare variants, fine mapping of susceptible loci, gene networking and their associated mechanism, copy number variations, single nucleotide polymorphisms in miRNAs (mirSNPs) and epigenetic changes in case control studies across cohorts of different ethnic groups would reveal a better insight.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Trends in Immunity

ISSN

2326-313X

e-ISSN

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Svazek periodika

1

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

43-54

Kód UT WoS článku

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EID výsledku v databázi Scopus

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