Systemic effect of asthma bronchiale on expression of multidrug resistance protein 1 in peripheral blood lymphocytes amongst children

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33144966" target="_blank" >RIV/61989592:15110/13:33144966 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Systemic effect of asthma bronchiale on expression of multidrug resistance protein 1 in peripheral blood lymphocytes amongst children

Popis výsledku v původním jazyce

It is influenced by the activity of the immune system and transports certain immunomodulatory drugs (e.g. glucocorticoids) from the intracellular to the extracellular space. Increased expression of the MDR1 protein in lymphocytes may therefore lead to undesirable reduction of lymphocytic concentration of these drugs. The aim of the study was to assess the systemic effect of asthma on the expression of the MDR1 protein in lymphocytes. The expression of MDR1 in peripheral blood lymphocytes (PBLs) was determined by a flow cytometry analysis with indirect immunofluorescence staining technique amongst 20 children (aged from 1.85 to 16.38 years) with newly diagnosed, mild persistent asthma (prior therapy) and amongst 30 healthy children (aged from 0.15 to 17.08 years). There was a significantly lower PBLs MDR1 expression (median MDR1 expression, p { 0.02) and a significantly lower proportion of the population of MDR1-positive PBLs as well (percentage of MDR1-postitive PBLs, p { 5.39.10-3)

Název v anglickém jazyce

Systemic effect of asthma bronchiale on expression of multidrug resistance protein 1 in peripheral blood lymphocytes amongst children

Popis výsledku anglicky

It is influenced by the activity of the immune system and transports certain immunomodulatory drugs (e.g. glucocorticoids) from the intracellular to the extracellular space. Increased expression of the MDR1 protein in lymphocytes may therefore lead to undesirable reduction of lymphocytic concentration of these drugs. The aim of the study was to assess the systemic effect of asthma on the expression of the MDR1 protein in lymphocytes. The expression of MDR1 in peripheral blood lymphocytes (PBLs) was determined by a flow cytometry analysis with indirect immunofluorescence staining technique amongst 20 children (aged from 1.85 to 16.38 years) with newly diagnosed, mild persistent asthma (prior therapy) and amongst 30 healthy children (aged from 0.15 to 17.08 years). There was a significantly lower PBLs MDR1 expression (median MDR1 expression, p { 0.02) and a significantly lower proportion of the population of MDR1-positive PBLs as well (percentage of MDR1-postitive PBLs, p { 5.39.10-3)

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FC - Pneumologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Alergie

ISSN

1212-3536

e-ISSN

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Svazek periodika

15

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

171-174

Kód UT WoS článku

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EID výsledku v databázi Scopus

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