STAT6 - polymorphisms, haplotypes and epistasis in relation to atopy and asthma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33145486" target="_blank" >RIV/61989592:15110/13:33145486 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/13:#0000530

Výsledek na webu

<a href="http://dx.doi.org/10.5507/bp.2013.043" target="_blank" >http://dx.doi.org/10.5507/bp.2013.043</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2013.043" target="_blank" >10.5507/bp.2013.043</a>

Jazyk výsledku

angličtina

Název v původním jazyce

STAT6 - polymorphisms, haplotypes and epistasis in relation to atopy and asthma

Popis výsledku v původním jazyce

Background. STAT6 has an important role in the IL-4/IL-13 signalling pathway. Genome - wide association studies have shown that particular polymorphism (SNP) or haplorype variants of STAT6 as well as epigenetic gene modifications are associated with IgElevel and astma in childhood. Methods. A review of the available literature was performed to map out the function and signalling patway of STAT6, studies of STAT6 SNP s association with susceptibility to asthma and atopy, covering the years 1997 - 2012 were summarized, and the value of epigenetic and epistatic influences on STAT6 and their relevance to the development of the studiend phenotype (atopy or asthma) were determined. Results. There are 2 SNPs (rs71802646 and rs320411) with clinical association and proven functional effect on STAT6 expression. The effect of STAT6 SNPs cumulates in haplotypes and more potently during interaction with SNPs in the genes from the signallling pathway (IL4, IL4Ra, and IL13). Expression of STAT6 is o

Název v anglickém jazyce

STAT6 - polymorphisms, haplotypes and epistasis in relation to atopy and asthma

Popis výsledku anglicky

Background. STAT6 has an important role in the IL-4/IL-13 signalling pathway. Genome - wide association studies have shown that particular polymorphism (SNP) or haplorype variants of STAT6 as well as epigenetic gene modifications are associated with IgElevel and astma in childhood. Methods. A review of the available literature was performed to map out the function and signalling patway of STAT6, studies of STAT6 SNP s association with susceptibility to asthma and atopy, covering the years 1997 - 2012 were summarized, and the value of epigenetic and epistatic influences on STAT6 and their relevance to the development of the studiend phenotype (atopy or asthma) were determined. Results. There are 2 SNPs (rs71802646 and rs320411) with clinical association and proven functional effect on STAT6 expression. The effect of STAT6 SNPs cumulates in haplotypes and more potently during interaction with SNPs in the genes from the signallling pathway (IL4, IL4Ra, and IL13). Expression of STAT6 is o

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

—

Svazek periodika

157

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

172-180

Kód UT WoS článku

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EID výsledku v databázi Scopus

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