Genetic variants of apolipoprotein A5 T-1131C and apolipoprotein E common polymorphisms and their relationship to features of metabolic syndrome in adult dyslipidemic patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150160" target="_blank" >RIV/61989592:15110/14:33150160 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/14:#0000721

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Genetic variants of apolipoprotein A5 T-1131C and apolipoprotein E common polymorphisms and their relationship to features of metabolic syndrome in adult dyslipidemic patients

Popis výsledku v původním jazyce

Objectives: The aim was to evaluate the relationships of the T-1131C (rs662799) polymorphism variants of apolipoprotein A5 (Apo A5) gene and variants of apolipopprotein E (ApoE) gene common polymorphism (rs429358,rs7412) to signs of metabolic syndrome (MetS). Design and methods: We examined 590 asymptomatic dyslipidemic patients divided into MetS + (n=146) and MetS - (n=444) groups according to criteria of NCEP ATPIII Panel. We evaluated genotype frequencies and differences in MetS feature between individual groups. Logistic regression analysis wes used for the evaluation of Apo A5/ApoE variants as possible risk factors for MetS. Conclusion: Our study refined the role of Apo A5 and Apo E genetic variants in the group of adult dyslipidemic patients. Wedemonstrate that except of TG, Apo A5 T-1131C (rs662799) and Apo E (rs429358, rs7412) polymorphisms have no remarkable effect on MetS characteristics.

Název v anglickém jazyce

Genetic variants of apolipoprotein A5 T-1131C and apolipoprotein E common polymorphisms and their relationship to features of metabolic syndrome in adult dyslipidemic patients

Popis výsledku anglicky

Objectives: The aim was to evaluate the relationships of the T-1131C (rs662799) polymorphism variants of apolipoprotein A5 (Apo A5) gene and variants of apolipopprotein E (ApoE) gene common polymorphism (rs429358,rs7412) to signs of metabolic syndrome (MetS). Design and methods: We examined 590 asymptomatic dyslipidemic patients divided into MetS + (n=146) and MetS - (n=444) groups according to criteria of NCEP ATPIII Panel. We evaluated genotype frequencies and differences in MetS feature between individual groups. Logistic regression analysis wes used for the evaluation of Apo A5/ApoE variants as possible risk factors for MetS. Conclusion: Our study refined the role of Apo A5 and Apo E genetic variants in the group of adult dyslipidemic patients. Wedemonstrate that except of TG, Apo A5 T-1131C (rs662799) and Apo E (rs429358, rs7412) polymorphisms have no remarkable effect on MetS characteristics.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

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Svazek periodika

47

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1015-1021

Kód UT WoS článku

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EID výsledku v databázi Scopus

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