The influence of apolipoprotein A5 T-1131C and apolipoprotein E common genetic variants on the levels of hemostatic markers in dyslipidemi patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150300" target="_blank" >RIV/61989592:15110/14:33150300 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/14:#0000738

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.cca.2014.04.029" target="_blank" >http://dx.doi.org/10.1016/j.cca.2014.04.029</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cca.2014.04.029" target="_blank" >10.1016/j.cca.2014.04.029</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The influence of apolipoprotein A5 T-1131C and apolipoprotein E common genetic variants on the levels of hemostatic markers in dyslipidemi patients

Popis výsledku v původním jazyce

Objectives: The aim of this study was to valuate the relationsips of the T-1131C (rs662799) polymorphism variants of apolipoprotein A5 (Apo A5) gene and variants of apolipoprotein E (Apo E) gene common polymorphism (rs429358, rs7412) to selected hemostatic markers. Study design and methods: We examined 590 asymptomatic dyslipidemic patients, subsequently divided into MetS + (n = 146) a MetS - (n = 444) groups according to the criteria for identification of the metabolic syndrome (MetS). We compared variant frequencies and differences in levels of hemostatic markers according to Apo A5, Apo E and Apo A5/Apo E common variants. Results: The 1131C Apo A5 minor variant was associated with elevated tissue plasminogen activator (tPA) in comparison to TT genotype (p{ 0,001), but not in the MetS + group. The analysis of Apo A5/Apo E common variants in all subjects revealed that the presence of -1131C minor allele has always been associated with higher levels of tP in comparison with T allele, r

Název v anglickém jazyce

The influence of apolipoprotein A5 T-1131C and apolipoprotein E common genetic variants on the levels of hemostatic markers in dyslipidemi patients

Popis výsledku anglicky

Objectives: The aim of this study was to valuate the relationsips of the T-1131C (rs662799) polymorphism variants of apolipoprotein A5 (Apo A5) gene and variants of apolipoprotein E (Apo E) gene common polymorphism (rs429358, rs7412) to selected hemostatic markers. Study design and methods: We examined 590 asymptomatic dyslipidemic patients, subsequently divided into MetS + (n = 146) a MetS - (n = 444) groups according to the criteria for identification of the metabolic syndrome (MetS). We compared variant frequencies and differences in levels of hemostatic markers according to Apo A5, Apo E and Apo A5/Apo E common variants. Results: The 1131C Apo A5 minor variant was associated with elevated tissue plasminogen activator (tPA) in comparison to TT genotype (p{ 0,001), but not in the MetS + group. The analysis of Apo A5/Apo E common variants in all subjects revealed that the presence of -1131C minor allele has always been associated with higher levels of tP in comparison with T allele, r

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinica Chimica Acta

ISSN

0009-8981

e-ISSN

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Svazek periodika

436

Číslo periodika v rámci svazku

duben

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

11-17

Kód UT WoS článku

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EID výsledku v databázi Scopus

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