Paraoxonase 2 Cys311Ser polymorphism and its association with the systolic blood pressure values in asymptomatic dyslipidemic individuals: A pilot study (Article)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33156561" target="_blank" >RIV/61989592:15110/15:33156561 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/15:#0000873

Výsledek na webu

<a href="http://dx.doi.org/10.1515/labmed-2015-0009" target="_blank" >http://dx.doi.org/10.1515/labmed-2015-0009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/labmed-2015-0009" target="_blank" >10.1515/labmed-2015-0009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Paraoxonase 2 Cys311Ser polymorphism and its association with the systolic blood pressure values in asymptomatic dyslipidemic individuals: A pilot study (Article)

Popis výsledku v původním jazyce

Background: The study aimed to evaluate the relationship of paraoxonase 2 (PON2) gene Cys311Ser variants with blood pressure values, endothelial/hemostatic marker levels, and other laboratory parameters in asymptomatic dyslipidemic subjects. The same analyses were also performed with the common variants of PON2 Cys311Ser and -T1131C apolipoprotein A5 (ApoA5) polymorphisms, and PON2 Cys311Ser and apolipoprotein E (ApoE) polymorphisms. Methods: Two hundred and sixty-four individuals were included in the study. The laboratory parameters were assessed by routine kit methods, while methods based on polymerase chain reaction were used for PON2, ApoA5, and ApoE genotyping. Results: PON2 311 SS homozygous individuals had significantly lower systolic blood pressure values (SBP, p<0.01), C-reactive protein, and apolipoprotein A1 levels (p<0.05), as compared with C allele carriers. The analysis revealed no differences in the levels of endothelial/hemostatic markers, except for the increased adhes

Název v anglickém jazyce

Paraoxonase 2 Cys311Ser polymorphism and its association with the systolic blood pressure values in asymptomatic dyslipidemic individuals: A pilot study (Article)

Popis výsledku anglicky

Background: The study aimed to evaluate the relationship of paraoxonase 2 (PON2) gene Cys311Ser variants with blood pressure values, endothelial/hemostatic marker levels, and other laboratory parameters in asymptomatic dyslipidemic subjects. The same analyses were also performed with the common variants of PON2 Cys311Ser and -T1131C apolipoprotein A5 (ApoA5) polymorphisms, and PON2 Cys311Ser and apolipoprotein E (ApoE) polymorphisms. Methods: Two hundred and sixty-four individuals were included in the study. The laboratory parameters were assessed by routine kit methods, while methods based on polymerase chain reaction were used for PON2, ApoA5, and ApoE genotyping. Results: PON2 311 SS homozygous individuals had significantly lower systolic blood pressure values (SBP, p<0.01), C-reactive protein, and apolipoprotein A1 levels (p<0.05), as compared with C allele carriers. The analysis revealed no differences in the levels of endothelial/hemostatic markers, except for the increased adhes

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Laboratory Medicine

ISSN

1439-0477

e-ISSN

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Svazek periodika

39

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

249-257

Kód UT WoS článku

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EID výsledku v databázi Scopus

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