Innate Immunity Sensors Participating in Pathophysiology of Joint Diseases: A Brief Overview

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33153071" target="_blank" >RIV/61989592:15110/14:33153071 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1615/JLongTermEffMedImplants.2014010825" target="_blank" >http://dx.doi.org/10.1615/JLongTermEffMedImplants.2014010825</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1615/JLongTermEffMedImplants.2014010825" target="_blank" >10.1615/JLongTermEffMedImplants.2014010825</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Innate Immunity Sensors Participating in Pathophysiology of Joint Diseases: A Brief Overview

Popis výsledku v původním jazyce

The innate immune system consists of functionally specialized "modules" that are activated in response to a particular set of stimuli via sensors located on the surface or inside the tissue cells. These cells screen tissues for a wide range of exogenousand endogenous danger/damage-induced signals with the aim to reject or tolerate them and maintain tissue integrity. In this line of thinking, inflammation evolved as an adaptive tool for restoring tissue homeostasis. A number of diseases are mediated bya maladaptation of the innate immune response, perpetuating chronic inflammation and tissue damage. Here, we review recent evidence on the cross talk between innate immune sensors and development of rheumatoid arthritis, osteoarthritis, and aseptic loosening of total joint replacements. In relation to the latter topic, there is a growing body of evidence that aseptic loosening and periprosthetic osteolysis results from long-term maladaptation of periprosthetic tissues to the presence of

Název v anglickém jazyce

Innate Immunity Sensors Participating in Pathophysiology of Joint Diseases: A Brief Overview

Popis výsledku anglicky

The innate immune system consists of functionally specialized "modules" that are activated in response to a particular set of stimuli via sensors located on the surface or inside the tissue cells. These cells screen tissues for a wide range of exogenousand endogenous danger/damage-induced signals with the aim to reject or tolerate them and maintain tissue integrity. In this line of thinking, inflammation evolved as an adaptive tool for restoring tissue homeostasis. A number of diseases are mediated bya maladaptation of the innate immune response, perpetuating chronic inflammation and tissue damage. Here, we review recent evidence on the cross talk between innate immune sensors and development of rheumatoid arthritis, osteoarthritis, and aseptic loosening of total joint replacements. In relation to the latter topic, there is a growing body of evidence that aseptic loosening and periprosthetic osteolysis results from long-term maladaptation of periprosthetic tissues to the presence of

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FI - Traumatologie a ortopedie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Long-Term Effects of Medical Implants

ISSN

1050-6934

e-ISSN

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Svazek periodika

24

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

21

Strana od-do

297-317

Kód UT WoS článku

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EID výsledku v databázi Scopus

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