Platelet-derived growth factor signaling in the lung. From lung development and disease to clinical studies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33154230" target="_blank" >RIV/61989592:15110/15:33154230 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1165/rcmb.2014-0294TR" target="_blank" >http://dx.doi.org/10.1165/rcmb.2014-0294TR</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1165/rcmb.2014-0294TR" target="_blank" >10.1165/rcmb.2014-0294TR</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Platelet-derived growth factor signaling in the lung. From lung development and disease to clinical studies

Popis výsledku v původním jazyce

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) represent one of the most intensively studied families of growth factors in the last four decades. PDGF signaling plays an essential role in cell proliferation, differentiation, migration, and survival. In vivo studies have documented an important role of PDGF signaling in the normal development of several organs, such as the kidney, eye, or lung. PDGF signaling is essential for the formation of intact mesenchymal cells during embryogenesis. Recently, this knowledge has been extended to a role of PDGF signaling in diseases in general, such as cancer and atherosclerosis, and more importantly in lung diseases, including pulmonary arterial hypertension, lung cancer, and lung fibrosis. Inthis review, we provide an up-to-date overview of PDGF signaling, including tissue- and cell-type-specific expression patterns and effects. We highlight current therapeutic approaches modifying PDGF signaling in lung diseases and summari

Název v anglickém jazyce

Platelet-derived growth factor signaling in the lung. From lung development and disease to clinical studies

Popis výsledku anglicky

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) represent one of the most intensively studied families of growth factors in the last four decades. PDGF signaling plays an essential role in cell proliferation, differentiation, migration, and survival. In vivo studies have documented an important role of PDGF signaling in the normal development of several organs, such as the kidney, eye, or lung. PDGF signaling is essential for the formation of intact mesenchymal cells during embryogenesis. Recently, this knowledge has been extended to a role of PDGF signaling in diseases in general, such as cancer and atherosclerosis, and more importantly in lung diseases, including pulmonary arterial hypertension, lung cancer, and lung fibrosis. Inthis review, we provide an up-to-date overview of PDGF signaling, including tissue- and cell-type-specific expression patterns and effects. We highlight current therapeutic approaches modifying PDGF signaling in lung diseases and summari

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Respiratory, Cell and Molecular Biology (print)

ISSN

1044-1549

e-ISSN

—

Svazek periodika

52

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

22

Strana od-do

263-284

Kód UT WoS článku

000352208100001

EID výsledku v databázi Scopus

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