Refractory immune thrombocytopenia. Successful treatment with repeated cyclosporine A: two case reports

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33154306" target="_blank" >RIV/61989592:15110/15:33154306 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ccr3.182" target="_blank" >http://dx.doi.org/10.1002/ccr3.182</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ccr3.182" target="_blank" >10.1002/ccr3.182</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Refractory immune thrombocytopenia. Successful treatment with repeated cyclosporine A: two case reports

Popis výsledku v původním jazyce

Treatment of chronic, severe refractory immune thrombocytopenia after sple- nectomy is difficult. Only less data exist on clinical use of cyclosporine A (CyA) in the management of refractory ITP. In this report, we describe two cases in which standard immunosuppressive therapy, other immunosuppression includ- ing cyclosporine A or splenectomy had no therapeutic effect. Even after sple- nectomy, recommended procedures were inefficient and critical thrombocytes count persisted. After repeated administration of cyclosporine A which had been ineffective prior to splenectomy; however, both patients achieved long- term complete remission of the ITP. Side effects of CyA were moderate. The presented cases have confirmed the potential therapeutic effect of CyAin refrac- tory post-SE ITP.

Název v anglickém jazyce

Refractory immune thrombocytopenia. Successful treatment with repeated cyclosporine A: two case reports

Popis výsledku anglicky

Treatment of chronic, severe refractory immune thrombocytopenia after sple- nectomy is difficult. Only less data exist on clinical use of cyclosporine A (CyA) in the management of refractory ITP. In this report, we describe two cases in which standard immunosuppressive therapy, other immunosuppression includ- ing cyclosporine A or splenectomy had no therapeutic effect. Even after sple- nectomy, recommended procedures were inefficient and critical thrombocytes count persisted. After repeated administration of cyclosporine A which had been ineffective prior to splenectomy; however, both patients achieved long- term complete remission of the ITP. Side effects of CyA were moderate. The presented cases have confirmed the potential therapeutic effect of CyAin refrac- tory post-SE ITP.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Case Reports

ISSN

2050-0904

e-ISSN

—

Svazek periodika

3

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

337-341

Kód UT WoS článku

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EID výsledku v databázi Scopus

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