A dataset of 26 candidate gene and pro-inflammatory cytokine variants for association studies in idiopathic pulmonary fibrosis: frequency distribution in normal Czech population

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33156197" target="_blank" >RIV/61989592:15110/15:33156197 - isvavai.cz</a>

Výsledek na webu

<a href="http://journal.frontiersin.org/article/10.3389/fimmu.2015.00476/full" target="_blank" >http://journal.frontiersin.org/article/10.3389/fimmu.2015.00476/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fimmu.2015.00476" target="_blank" >10.3389/fimmu.2015.00476</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A dataset of 26 candidate gene and pro-inflammatory cytokine variants for association studies in idiopathic pulmonary fibrosis: frequency distribution in normal Czech population

Popis výsledku v původním jazyce

Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive fibrosing interstitial pneumonia with poor diagnosis and a median survival of 2-3 years from initial diagnosis. The cellular inflammation drives the fibrotic response in lungand plays a major role in IPF pathogenesis. Inflammatory cells (majorly, type 2 alveolar epithelial cells) release TGF-?, the key mediator of pulmonary fibrosis, that regulates several profibrotic cytokines/chemokines, their receptors, receptor subunits,and growth factors inducing process of epithelial-mesenchymal transition (EMT). Among the pro-inflammatory and profibrotic cytokines involved in IPF pathogenesis, interleukin (IL)-1, IL-1?, IL-4, IL-5, IL-6R?, angiogenic IL-8/CXCL-8, IL-13, its receptorIL-13 R?2, and IL-33 have been implicated in accelerated inflammation and irreversible damage to lung architecture with loss of alveolar-capillary barrier basal membrane leading to persistent fibrosis. Genes encoding these factors exhibi

Název v anglickém jazyce

A dataset of 26 candidate gene and pro-inflammatory cytokine variants for association studies in idiopathic pulmonary fibrosis: frequency distribution in normal Czech population

Popis výsledku anglicky

Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive fibrosing interstitial pneumonia with poor diagnosis and a median survival of 2-3 years from initial diagnosis. The cellular inflammation drives the fibrotic response in lungand plays a major role in IPF pathogenesis. Inflammatory cells (majorly, type 2 alveolar epithelial cells) release TGF-?, the key mediator of pulmonary fibrosis, that regulates several profibrotic cytokines/chemokines, their receptors, receptor subunits,and growth factors inducing process of epithelial-mesenchymal transition (EMT). Among the pro-inflammatory and profibrotic cytokines involved in IPF pathogenesis, interleukin (IL)-1, IL-1?, IL-4, IL-5, IL-6R?, angiogenic IL-8/CXCL-8, IL-13, its receptorIL-13 R?2, and IL-33 have been implicated in accelerated inflammation and irreversible damage to lung architecture with loss of alveolar-capillary barrier basal membrane leading to persistent fibrosis. Genes encoding these factors exhibi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Immunology

ISSN

1664-3224

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

1-7

Kód UT WoS článku

000361912300001

EID výsledku v databázi Scopus

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