First Report of the Global SYMPLICITY Registry on the Effect of Renal Artery Denervation in Patients With Uncontrolled Hypertension

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F15%3A33157676" target="_blank" >RIV/61989592:15110/15:33157676 - isvavai.cz</a>

Výsledek na webu

<a href="http://hyper.ahajournals.org/content/65/4/766.long" target="_blank" >http://hyper.ahajournals.org/content/65/4/766.long</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.05010" target="_blank" >10.1161/HYPERTENSIONAHA.114.05010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

First Report of the Global SYMPLICITY Registry on the Effect of Renal Artery Denervation in Patients With Uncontrolled Hypertension

Popis výsledku v původním jazyce

This study aimed to assess the safety and effectiveness of renal denervation using the Symplicity system in real-world patients with uncontrolled hypertension (NCT01534299). The Global SYMPLICITY Registry is a prospective, open-label, multicenter registry. Office and 24-hour ambulatory blood pressures (BPs) were measured. Change from baseline to 6 months was analyzed for all patients and for subgroups based on baseline office systolic BP, diabetic status, and renal function; a cohort with severe hypertension (office systolic pressure, GREATER-THAN OR EQUAL TO160 mm Hg; 24-hour systolic pressure, GREATER-THAN OR EQUAL TO135 mm Hg; and GREATER-THAN OR EQUAL TO3 antihypertensive medication classes) was also included. The analysis included protocol-definedsafety events. Six-month outcomes for 998 patients, including 323 in the severe hypertension cohort, are reported. Mean baseline office systolic BP was 163.5+-24.0 mm Hg for all patients and 179.3+-16.5 mm Hg for the severe cohort; the c

Název v anglickém jazyce

First Report of the Global SYMPLICITY Registry on the Effect of Renal Artery Denervation in Patients With Uncontrolled Hypertension

Popis výsledku anglicky

This study aimed to assess the safety and effectiveness of renal denervation using the Symplicity system in real-world patients with uncontrolled hypertension (NCT01534299). The Global SYMPLICITY Registry is a prospective, open-label, multicenter registry. Office and 24-hour ambulatory blood pressures (BPs) were measured. Change from baseline to 6 months was analyzed for all patients and for subgroups based on baseline office systolic BP, diabetic status, and renal function; a cohort with severe hypertension (office systolic pressure, GREATER-THAN OR EQUAL TO160 mm Hg; 24-hour systolic pressure, GREATER-THAN OR EQUAL TO135 mm Hg; and GREATER-THAN OR EQUAL TO3 antihypertensive medication classes) was also included. The analysis included protocol-definedsafety events. Six-month outcomes for 998 patients, including 323 in the severe hypertension cohort, are reported. Mean baseline office systolic BP was 163.5+-24.0 mm Hg for all patients and 179.3+-16.5 mm Hg for the severe cohort; the c

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Hypertension

ISSN

0073-425X

e-ISSN

—

Svazek periodika

65

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

766-774

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—