How Much Evidence do we have on the Central Effects of Botulinum Toxin in Spasticity and Dystonia?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F16%3A33160717" target="_blank" >RIV/61989592:15110/16:33160717 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.5772/64763" target="_blank" >http://dx.doi.org/10.5772/64763</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/64763" target="_blank" >10.5772/64763</a>

Jazyk výsledku

angličtina

Název v původním jazyce

How Much Evidence do we have on the Central Effects of Botulinum Toxin in Spasticity and Dystonia?

Popis výsledku v původním jazyce

Abstract The brain is continually reorganizing (plasticity). Plastic changes within the sensorimotor system are not only beneficial (adaptive plasticity) but may even worsen function (maladaptive plasticity). Conditions such as dystonia and poststroke spasticity (PSS) that interfere with motor performance could be attributed to maladaptive plasticity. Botulinum toxin (BoNT) has been proven to be safe and effective in treating various hyperfunctional cholinergic states. Beside the well-known neuromuscular junction site of action, BoNT also exerts effects through supraspinal mechanisms and can even affect cortical reorganization. The hypothesis of central reorganization following BoNT treatment has been supported by studies using neurophysiological and imaging methods in patients with focal dystonia and PSS. The growing evidence of BoNT-related central (remote) effects make BoNT injections a promising tool to favorably affect maladaptive changes even at the cortical level.

Název v anglickém jazyce

How Much Evidence do we have on the Central Effects of Botulinum Toxin in Spasticity and Dystonia?

Popis výsledku anglicky

Abstract The brain is continually reorganizing (plasticity). Plastic changes within the sensorimotor system are not only beneficial (adaptive plasticity) but may even worsen function (maladaptive plasticity). Conditions such as dystonia and poststroke spasticity (PSS) that interfere with motor performance could be attributed to maladaptive plasticity. Botulinum toxin (BoNT) has been proven to be safe and effective in treating various hyperfunctional cholinergic states. Beside the well-known neuromuscular junction site of action, BoNT also exerts effects through supraspinal mechanisms and can even affect cortical reorganization. The hypothesis of central reorganization following BoNT treatment has been supported by studies using neurophysiological and imaging methods in patients with focal dystonia and PSS. The growing evidence of BoNT-related central (remote) effects make BoNT injections a promising tool to favorably affect maladaptive changes even at the cortical level.

Druh

C - Kapitola v odborné knize

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NV15-31921A" target="_blank" >NV15-31921A: Prevalence spasticity v populaci pacientů postižených ischemickým iktem v karotickém povodí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Botulinum Toxin Therapy Manual for Dystonia and Spasticity

ISBN

978-953-51-2852-6

Počet stran výsledku

9

Strana od-do

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Počet stran knihy

180

Název nakladatele

IN TECH d.o.o.

Místo vydání

Rijeka

Kód UT WoS kapitoly

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