Chromosome 6q deletion correlates with poor prognosis and low relative expression of FOXO3 in chronic lymphocytic leukemia patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73581117" target="_blank" >RIV/61989592:15110/17:73581117 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/17:00067568 RIV/00669806:_____/17:10363732 RIV/00216224:14110/17:00095685 RIV/00098892:_____/17:N0000140

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ajh.24852" target="_blank" >http://dx.doi.org/10.1002/ajh.24852</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ajh.24852" target="_blank" >10.1002/ajh.24852</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chromosome 6q deletion correlates with poor prognosis and low relative expression of FOXO3 in chronic lymphocytic leukemia patients

Popis výsledku v původním jazyce

Detection of genetic changes has improved the current risk stratifica-tion in chronic lymphocytic leukemia (CLL).1,2Among the known recur-rent chromosomal abnormalities,16q deletion is less frequent andcontroversy surrounding its prognostic significance still remains.3,4The study aimed at a genetic analysis of a group of CLL patientswith chromosome 6q deletion for determination of its prognostic sig-nificance, extent, the minimal deleted region (MDR) using array com-parative genomic hybridization (arrayCGH), and finally to dermine therelative expression of candidate genes located therein.Peripheral blood and/or bone marrow samples from 1158 CLLpatients diagnosed and treated in three Czech hematology centers(Brno, Olomouc and Pilsen) were examined in 2001–2016 usingconventional cytogenetics (CG) and FISH. The patient characteristicsare listed in Supporting Information Table S1. Chromosome 6q dele-tion was found by CG (53) and FISH (38) in a total of 91 (7.9%)patients. Complete data and material for further analysis were avail-able for only 70 patients, including 42 patients examined at CLLdiagnosis and 28 treated patients examined in the course of the dis-ease (Table 1).Deletion 6q was confirmed as a single aberration in 10 patients,together with one additional aberration in 21 and as part of a complexkaryotype in 39 patients. Evaluation of the frequency of other changesusing a FISH CLL panel1showed that 13q deletion was the most fre-quent change regardless of the number of changes, occurring in 30/70(42.8%) patients. TP53 deletion was present in 17 (24.3%) patients,with 13 of them having a complex karyotype. The results concerningthe presence of additional changes identified by CG and FISH areshown in Supporting Information Figure S1

Název v anglickém jazyce

Chromosome 6q deletion correlates with poor prognosis and low relative expression of FOXO3 in chronic lymphocytic leukemia patients

Popis výsledku anglicky

Detection of genetic changes has improved the current risk stratifica-tion in chronic lymphocytic leukemia (CLL).1,2Among the known recur-rent chromosomal abnormalities,16q deletion is less frequent andcontroversy surrounding its prognostic significance still remains.3,4The study aimed at a genetic analysis of a group of CLL patientswith chromosome 6q deletion for determination of its prognostic sig-nificance, extent, the minimal deleted region (MDR) using array com-parative genomic hybridization (arrayCGH), and finally to dermine therelative expression of candidate genes located therein.Peripheral blood and/or bone marrow samples from 1158 CLLpatients diagnosed and treated in three Czech hematology centers(Brno, Olomouc and Pilsen) were examined in 2001–2016 usingconventional cytogenetics (CG) and FISH. The patient characteristicsare listed in Supporting Information Table S1. Chromosome 6q dele-tion was found by CG (53) and FISH (38) in a total of 91 (7.9%)patients. Complete data and material for further analysis were avail-able for only 70 patients, including 42 patients examined at CLLdiagnosis and 28 treated patients examined in the course of the dis-ease (Table 1).Deletion 6q was confirmed as a single aberration in 10 patients,together with one additional aberration in 21 and as part of a complexkaryotype in 39 patients. Evaluation of the frequency of other changesusing a FISH CLL panel1showed that 13q deletion was the most fre-quent change regardless of the number of changes, occurring in 30/70(42.8%) patients. TP53 deletion was present in 17 (24.3%) patients,with 13 of them having a complex karyotype. The results concerningthe presence of additional changes identified by CG and FISH areshown in Supporting Information Figure S1

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Hematology

ISSN

0361-8609

e-ISSN

—

Svazek periodika

92

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

"E604"-"E607"

Kód UT WoS článku

000409203200010

EID výsledku v databázi Scopus

2-s2.0-85026459512