Age-Related Differences in Non-Persistence with Statin Treatment in Patients after a Transient Ischaemic Attack

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73581608" target="_blank" >RIV/61989592:15110/17:73581608 - isvavai.cz</a>

Výsledek na webu

<a href="https://obd.upol.cz/id_publ/333161493" target="_blank" >https://obd.upol.cz/id_publ/333161493</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40261-017-0559-3" target="_blank" >10.1007/s40261-017-0559-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Age-Related Differences in Non-Persistence with Statin Treatment in Patients after a Transient Ischaemic Attack

Popis výsledku v původním jazyce

Non-persistence with secondary preventive measures, including medications such as statins, adversely affects the prospects of successful outcomes. This study was aimed at evaluating non-persistence with statin therapy in cohorts of young and elderly patients after a transient ischaemic attack (TIA) and identifying patient-associated characteristics that influence the risk for non-persistence. Methods The study cohorts included 797 adult patients who were initiated on statin therapy following a TIA diagnosis between 1 January 2010 and 31 December 2010. Patients were followed up for 3 years and those with a treatment gap of at least a 6-month period were considered ‘non-persistent’. In order to identify any age-related differences, all analyses were conducted in the entire study cohort (n = 797) as well as separately in the ‘younger’(aged 65 years, n = 267) and the ‘older’ (aged C65 years, n = 530) patients. Results Non-persistence was significantly more common in younger patients compared to older patients (67.8% vs. 49.1%; p.001). Factors that decreased the probability of non-persistence in younger and older patients included diabetes mellitus (hazard ratio [HR] = 0.72 and HR = 0.64, respectively) and hypercholesterolaemia (HR = 0.43 and HR = 0.62, respectively). Female gender (HR = 1.42) was associated with a higher and increasing number of medications taken (HR = 0.93), with lower probability for non-persistence in younger patients but not in the older patients. Our results indicate that certain patients with TIA require special counselling to improve persistence with statin therapy. These include younger patients, especially females and those not on polypharmacy, and bothyounger and older patients without diabetes mellitus or hypercholesterolaemia.

Název v anglickém jazyce

Age-Related Differences in Non-Persistence with Statin Treatment in Patients after a Transient Ischaemic Attack

Popis výsledku anglicky

Non-persistence with secondary preventive measures, including medications such as statins, adversely affects the prospects of successful outcomes. This study was aimed at evaluating non-persistence with statin therapy in cohorts of young and elderly patients after a transient ischaemic attack (TIA) and identifying patient-associated characteristics that influence the risk for non-persistence. Methods The study cohorts included 797 adult patients who were initiated on statin therapy following a TIA diagnosis between 1 January 2010 and 31 December 2010. Patients were followed up for 3 years and those with a treatment gap of at least a 6-month period were considered ‘non-persistent’. In order to identify any age-related differences, all analyses were conducted in the entire study cohort (n = 797) as well as separately in the ‘younger’(aged 65 years, n = 267) and the ‘older’ (aged C65 years, n = 530) patients. Results Non-persistence was significantly more common in younger patients compared to older patients (67.8% vs. 49.1%; p.001). Factors that decreased the probability of non-persistence in younger and older patients included diabetes mellitus (hazard ratio [HR] = 0.72 and HR = 0.64, respectively) and hypercholesterolaemia (HR = 0.43 and HR = 0.62, respectively). Female gender (HR = 1.42) was associated with a higher and increasing number of medications taken (HR = 0.93), with lower probability for non-persistence in younger patients but not in the older patients. Our results indicate that certain patients with TIA require special counselling to improve persistence with statin therapy. These include younger patients, especially females and those not on polypharmacy, and bothyounger and older patients without diabetes mellitus or hypercholesterolaemia.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Drug Investigation

ISSN

1173-2563

e-ISSN

—

Svazek periodika

37

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

NZ - Nový Zéland

Počet stran výsledku

8

Strana od-do

1047-1054

Kód UT WoS článku

000413102400005

EID výsledku v databázi Scopus

2-s2.0-85027080089