Cerebrospinal fluid and serum levels of interleukin-8 in patients with multiple sclerosis and its correlation with Q-albumin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73583294" target="_blank" >RIV/61989592:15110/17:73583294 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/17:N0000016

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.msard.2017.03.007" target="_blank" >http://dx.doi.org/10.1016/j.msard.2017.03.007</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.msard.2017.03.007" target="_blank" >10.1016/j.msard.2017.03.007</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cerebrospinal fluid and serum levels of interleukin-8 in patients with multiple sclerosis and its correlation with Q-albumin

Popis výsledku v původním jazyce

Abstract INTRODUCTION: Multiple sclerosis (MS) is an inflammatory-demyelinating disease of the central nervous system (CNS). Autoimmune inflammation is common in the early stages of MS and is followed by neurodegenerative processes. The result of these changes is axon and myelin breakdown. The paraclinical examination methods are an important part of the diagnostic process. Magnetic resonance imaging of the brain and the cervical spinal cord and an examination of cerebrospinal fluid (CSF) are common paraclinical examinations. An increasing number of studies deal with CSF and serum levels of biomarkers and their role in MS. We hypothesized that the level of interleukin-8 (IL-8) could be different in MS patients than in controls. These differences may be related to damage of the blood-brain barrier (BBB). BBB damage is quantified by the quotient of albumin (Q-alb). METHODS: CSF and serum levels of IL-8 were assessed in 102 patients with newly diagnosed MS meeting McDonald&apos;s revised diagnostic criteria and in 102 subjects as a control group. We then correlated these results with Q-alb. RESULTS: Levels of IL-8 in CSF were significantly higher in MS patients than in controls (Mann-Whitney U test, p&lt;0.0001). Serum levels of IL-8 were significantly lower in MS patients than in controls (Mann-Whitney U test, p=0.018). Spearman&apos;s correlation analysis proved a significant correlation between levels of IL-8 and Q-alb. CONCLUSION: As the etiology of MS is only partially known, research dealing with biomarkers in MS should continue. Better knowledge of etiology can provide a new perspective, especially for treatment.

Název v anglickém jazyce

Cerebrospinal fluid and serum levels of interleukin-8 in patients with multiple sclerosis and its correlation with Q-albumin

Popis výsledku anglicky

Abstract INTRODUCTION: Multiple sclerosis (MS) is an inflammatory-demyelinating disease of the central nervous system (CNS). Autoimmune inflammation is common in the early stages of MS and is followed by neurodegenerative processes. The result of these changes is axon and myelin breakdown. The paraclinical examination methods are an important part of the diagnostic process. Magnetic resonance imaging of the brain and the cervical spinal cord and an examination of cerebrospinal fluid (CSF) are common paraclinical examinations. An increasing number of studies deal with CSF and serum levels of biomarkers and their role in MS. We hypothesized that the level of interleukin-8 (IL-8) could be different in MS patients than in controls. These differences may be related to damage of the blood-brain barrier (BBB). BBB damage is quantified by the quotient of albumin (Q-alb). METHODS: CSF and serum levels of IL-8 were assessed in 102 patients with newly diagnosed MS meeting McDonald&apos;s revised diagnostic criteria and in 102 subjects as a control group. We then correlated these results with Q-alb. RESULTS: Levels of IL-8 in CSF were significantly higher in MS patients than in controls (Mann-Whitney U test, p&lt;0.0001). Serum levels of IL-8 were significantly lower in MS patients than in controls (Mann-Whitney U test, p=0.018). Spearman&apos;s correlation analysis proved a significant correlation between levels of IL-8 and Q-alb. CONCLUSION: As the etiology of MS is only partially known, research dealing with biomarkers in MS should continue. Better knowledge of etiology can provide a new perspective, especially for treatment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Multiple Sclerosis and Related Disorders

ISSN

2211-0348

e-ISSN

—

Svazek periodika

2017

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

12-15

Kód UT WoS článku

000405049900005

EID výsledku v databázi Scopus

2-s2.0-85015771034