Newborn foal with atypical myopathy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73587064" target="_blank" >RIV/61989592:15110/18:73587064 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61389030:_____/18:00495766 RIV/00098892:_____/18:N0000010

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189353/pdf/JVIM-32-1768.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189353/pdf/JVIM-32-1768.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jvim.15236" target="_blank" >10.1111/jvim.15236</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Newborn foal with atypical myopathy

Popis výsledku v původním jazyce

The case of atypical myopathy (AM) in newborn Haflinger foal with clinical signs of depression and weakness appearing 6 hours after birth resulting in recumbency 12 hours after birth is described. The foal’s dam was diagnosed with AM in the 6th month of gestation based on clinical signs of a myopathy, elevated serum activity of creatine kinase, metabolomic analysis and the presence of methylenecyclopropyl acetyl carnitine (MCPA-carnitine) in the blood. At the time of delivery, the mare was grazing on a pasture near sycamore trees but was free of clinical signs of AM. Metabolomic analysis of the foal’s blood revealed increased concentrations of acylcarnitines and MCPA-carnitine consistent with metabolic profiles of blood from AM affected horses. Two theories could explain this observation (a) hypoglycin A or its metabolites accumulated in the mare’s placenta with consequent transfer to fetus or (b) these compounds were secreted into mare’s milk.

Název v anglickém jazyce

Newborn foal with atypical myopathy

Popis výsledku anglicky

The case of atypical myopathy (AM) in newborn Haflinger foal with clinical signs of depression and weakness appearing 6 hours after birth resulting in recumbency 12 hours after birth is described. The foal’s dam was diagnosed with AM in the 6th month of gestation based on clinical signs of a myopathy, elevated serum activity of creatine kinase, metabolomic analysis and the presence of methylenecyclopropyl acetyl carnitine (MCPA-carnitine) in the blood. At the time of delivery, the mare was grazing on a pasture near sycamore trees but was free of clinical signs of AM. Metabolomic analysis of the foal’s blood revealed increased concentrations of acylcarnitines and MCPA-carnitine consistent with metabolic profiles of blood from AM affected horses. Two theories could explain this observation (a) hypoglycin A or its metabolites accumulated in the mare’s placenta with consequent transfer to fetus or (b) these compounds were secreted into mare’s milk.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF VETERINARY INTERNAL MEDICINE

ISSN

1939-1676

e-ISSN

—

Svazek periodika

32

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

1768-1772

Kód UT WoS článku

000447414300034

EID výsledku v databázi Scopus

2-s2.0-85053623609