Effects of age on left ventricular diastolic function

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73592007" target="_blank" >RIV/61989592:15110/19:73592007 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.researchgate.net/publication/329214760_Effects_of_age_on_left_ventricular_diastolic_function" target="_blank" >https://www.researchgate.net/publication/329214760_Effects_of_age_on_left_ventricular_diastolic_function</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.crvasa.2018.10.003" target="_blank" >10.1016/j.crvasa.2018.10.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of age on left ventricular diastolic function

Popis výsledku v původním jazyce

Introduction: Echocardiography plays a pivotal role in the diagnosis of left ventricular diastolic function. There has been only limited data on effects of age on different parameters of left ventricular diastolic function. Methods: We retrospectively searched and analysed a computerised echocardiography database data of subjects investigated at our department. We enrolled only subjects with sinus rhythm, normal left ventricular ejection fraction, without any valvular disease or any other significant echocardiographic pathology. By a subsequent manual search of hospital records we divided subjects into three groups based on their clinical history – group of healthy patients, group of patients with arterial hypertension and a group with coronary artery disease. Results: We enrolled a total of 999 subjects, mean age 60.1 ± 14.4 years, 48.5% were men. There were 363 healthy subjects, 429 subjects with arterial hypertension and 207 subjects with coronary artery disease. Transmitral E/A ratio decreased with age from mean 1.65 in subjects aged under 30 years to 0.78 in subjects over 80 years of age (P &lt; 0.001). Tissue doppler velocities of septal and lateral mitral anulus (Em sep and Em lat) decreased with age, as did the septal and lateral e′/a′ ratio. The septal, lateral and average E/Em ratio increased with age, as did the E wave deceleration time (DtE) (all parameters with P &lt; 0.001). Except for DtE, Chi-square goodness of fit test did not find any statistically significant differences in the measured parameters between the three compared groups. Conclusions: Echocardiographic parameters of diastolic function physiologically deteriorate with age. Based on this study, more exact cut-off values can be adopted for different age groups and measured diastolic parameters, than are currently available.

Název v anglickém jazyce

Effects of age on left ventricular diastolic function

Popis výsledku anglicky

Introduction: Echocardiography plays a pivotal role in the diagnosis of left ventricular diastolic function. There has been only limited data on effects of age on different parameters of left ventricular diastolic function. Methods: We retrospectively searched and analysed a computerised echocardiography database data of subjects investigated at our department. We enrolled only subjects with sinus rhythm, normal left ventricular ejection fraction, without any valvular disease or any other significant echocardiographic pathology. By a subsequent manual search of hospital records we divided subjects into three groups based on their clinical history – group of healthy patients, group of patients with arterial hypertension and a group with coronary artery disease. Results: We enrolled a total of 999 subjects, mean age 60.1 ± 14.4 years, 48.5% were men. There were 363 healthy subjects, 429 subjects with arterial hypertension and 207 subjects with coronary artery disease. Transmitral E/A ratio decreased with age from mean 1.65 in subjects aged under 30 years to 0.78 in subjects over 80 years of age (P &lt; 0.001). Tissue doppler velocities of septal and lateral mitral anulus (Em sep and Em lat) decreased with age, as did the septal and lateral e′/a′ ratio. The septal, lateral and average E/Em ratio increased with age, as did the E wave deceleration time (DtE) (all parameters with P &lt; 0.001). Except for DtE, Chi-square goodness of fit test did not find any statistically significant differences in the measured parameters between the three compared groups. Conclusions: Echocardiographic parameters of diastolic function physiologically deteriorate with age. Based on this study, more exact cut-off values can be adopted for different age groups and measured diastolic parameters, than are currently available.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

COR ET VASA

ISSN

0010-8650

e-ISSN

—

Svazek periodika

61

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

4

Strana od-do

"e28"-"e31"

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85057084951