Assessment of late cardiotoxic effects in patients treated for cancer in childhood

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076100" target="_blank" >RIV/00159816:_____/22:00076100 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/22:00076100 RIV/00216224:14110/22:00128258

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/cam4.4564" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/cam4.4564</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/cam4.4564" target="_blank" >10.1002/cam4.4564</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Assessment of late cardiotoxic effects in patients treated for cancer in childhood

Popis výsledku v původním jazyce

Background: The most frequent chemotherapeutic regimens used in children&apos;s cancer contain anthracyclines, which may have potentially cardiotoxic effects even at a later point in time. Echocardiography including tissue Doppler imaging is well-proved noninvasive method to assess cardiac function. Objectives: To assess the late cardiotoxic effects in young adults treated for various cancer types in childhood. Methods: Ninety-eight young adults who were treated for childhood cancer (CCS), median time 12.1 years after finishing the therapy, were comprised into study. All subjects underwent echocardiographic examination including tissue Doppler imaging. The echocardiographic parameters were compared to 57 healthy age-matched subjects. The CCS group also underwent 24-h ECG Holter monitoring to reveal any arrhythmias. Results: The subjects in CCS group had lower E&apos; velocities from lateral (15.6 vs. 17.6 cm/s) and septal part (12.2 vs. 14.4 cm/s) of mitral annulus (p for both &lt;0.001) and also lower S&apos; velocity from the tricuspid annulus (12.4. vs. 13.3 cm/s, p = 0.013) and tricuspid annulus peak systolic excursion (TAPSE; 22.2 vs. 23.9 mm, p = 0.017). There were no significant differences in left ventricular systolic velocities or ejection fraction. The occurrence of arrhythmias did not differ among subgroups of CCS with or without anthracycline therapy. Conclusion: Childhood cancer survivors had subclinical cardiac impairment in comparison with healthy controls, particularly in left ventricular diastolic function.

Název v anglickém jazyce

Assessment of late cardiotoxic effects in patients treated for cancer in childhood

Popis výsledku anglicky

Background: The most frequent chemotherapeutic regimens used in children&apos;s cancer contain anthracyclines, which may have potentially cardiotoxic effects even at a later point in time. Echocardiography including tissue Doppler imaging is well-proved noninvasive method to assess cardiac function. Objectives: To assess the late cardiotoxic effects in young adults treated for various cancer types in childhood. Methods: Ninety-eight young adults who were treated for childhood cancer (CCS), median time 12.1 years after finishing the therapy, were comprised into study. All subjects underwent echocardiographic examination including tissue Doppler imaging. The echocardiographic parameters were compared to 57 healthy age-matched subjects. The CCS group also underwent 24-h ECG Holter monitoring to reveal any arrhythmias. Results: The subjects in CCS group had lower E&apos; velocities from lateral (15.6 vs. 17.6 cm/s) and septal part (12.2 vs. 14.4 cm/s) of mitral annulus (p for both &lt;0.001) and also lower S&apos; velocity from the tricuspid annulus (12.4. vs. 13.3 cm/s, p = 0.013) and tricuspid annulus peak systolic excursion (TAPSE; 22.2 vs. 23.9 mm, p = 0.017). There were no significant differences in left ventricular systolic velocities or ejection fraction. The occurrence of arrhythmias did not differ among subgroups of CCS with or without anthracycline therapy. Conclusion: Childhood cancer survivors had subclinical cardiac impairment in comparison with healthy controls, particularly in left ventricular diastolic function.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

<a href="/cs/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molekulární, buněčný a klinický přístup ke zdravému stárnutí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer Medicine

ISSN

2045-7634

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

1763-1768

Kód UT WoS článku

000761794900001

EID výsledku v databázi Scopus

2-s2.0-85124531828