Modifying the Siderophore Triacetylfusarinine C for Molecular Imaging of Fungal Infection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73593985" target="_blank" >RIV/61989592:15110/19:73593985 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s11307-019-01325-6" target="_blank" >https://link.springer.com/article/10.1007/s11307-019-01325-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11307-019-01325-6" target="_blank" >10.1007/s11307-019-01325-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Modifying the Siderophore Triacetylfusarinine C for Molecular Imaging of Fungal Infection

Popis výsledku v původním jazyce

Due to the lack of sensitivity and specificity of current diagnostic methods, invasive fungal diseases are a major cause of high mortality rates (up to 50 % [1, 2]) and elevated healthcare costs in Europe [3]. Aspergillus fumigatus is the major cause for pulmonary fungal infections in immunocompromised patients including also transplant recipients and patients undergoing aggressive anti-cancer chemotherapy [4]. Early diagnosis of invasive pulmonary aspergillosis (IPA) is a key to improve survival rate. Various clinical tests and techniques as well as X-ray computed tomography (CT) have shown unsuccessful diagnosis in terms of specificity and sensitivity. Scintigraphic techniques such as single photon emission computer tomography (SPECT) and positron emission tomography (PET) have been applied for imaging fungal infections using non-specific radiotracers including [99mTc]leucocytes, [99mTc]peptides, [99mTc]anti-granulocyte antibody, [67Ga]citrate (inflammation radiotracer), and even 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) [5]. These tracers have revealed only suboptimal characteristics for fungal detection.

Název v anglickém jazyce

Modifying the Siderophore Triacetylfusarinine C for Molecular Imaging of Fungal Infection

Popis výsledku anglicky

Due to the lack of sensitivity and specificity of current diagnostic methods, invasive fungal diseases are a major cause of high mortality rates (up to 50 % [1, 2]) and elevated healthcare costs in Europe [3]. Aspergillus fumigatus is the major cause for pulmonary fungal infections in immunocompromised patients including also transplant recipients and patients undergoing aggressive anti-cancer chemotherapy [4]. Early diagnosis of invasive pulmonary aspergillosis (IPA) is a key to improve survival rate. Various clinical tests and techniques as well as X-ray computed tomography (CT) have shown unsuccessful diagnosis in terms of specificity and sensitivity. Scintigraphic techniques such as single photon emission computer tomography (SPECT) and positron emission tomography (PET) have been applied for imaging fungal infections using non-specific radiotracers including [99mTc]leucocytes, [99mTc]peptides, [99mTc]anti-granulocyte antibody, [67Ga]citrate (inflammation radiotracer), and even 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) [5]. These tracers have revealed only suboptimal characteristics for fungal detection.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molekulární, buněčný a klinický přístup ke zdravému stárnutí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MOLECULAR IMAGING AND BIOLOGY

ISSN

1536-1632

e-ISSN

—

Svazek periodika

2019

Číslo periodika v rámci svazku

1536-1632

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

1-10

Kód UT WoS článku

000497304600011

EID výsledku v databázi Scopus

2-s2.0-85062667316