Radiotracer Development for Fungal-Specific Imaging: Past, Present, and Future

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15640%2F23%3A73622092" target="_blank" >RIV/61989592:15640/23:73622092 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/23:73622092

Výsledek na webu

<a href="https://academic.oup.com/jid/article/228/Supplement_4/S259/7288373?login=true" target="_blank" >https://academic.oup.com/jid/article/228/Supplement_4/S259/7288373?login=true</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/infdis/jiad067" target="_blank" >10.1093/infdis/jiad067</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Radiotracer Development for Fungal-Specific Imaging: Past, Present, and Future

Popis výsledku v původním jazyce

Invasive fungal infections have become a major challenge for public health, mainly due to the growing numbers of immunocompromised patients, with high morbidity and mortality. Currently, conventional imaging modalities such as computed tomography and magnetic resonance imaging contribute largely to the noninvasive diagnosis and treatment evaluation of those infections. These techniques, however, often fall short when a fast, noninvasive and specific diagnosis of fungal infection is necessary. Molecular imaging, especially using nuclear medicine-based techniques, aims to develop fungal-specific radiotracers that can be tested in preclinical models and eventually translated to human applications. In the last few decades, multiple radioligands have been developed and tested as potential fungal-specific tracers. These include radiolabeled peptides, antifungal drugs, siderophores, fungal-specific antibodies, and sugars. In this review, we provide an overview of the pros and cons of the available radiotracers. We also address the future prospects of fungal-specific imaging.

Název v anglickém jazyce

Radiotracer Development for Fungal-Specific Imaging: Past, Present, and Future

Popis výsledku anglicky

Invasive fungal infections have become a major challenge for public health, mainly due to the growing numbers of immunocompromised patients, with high morbidity and mortality. Currently, conventional imaging modalities such as computed tomography and magnetic resonance imaging contribute largely to the noninvasive diagnosis and treatment evaluation of those infections. These techniques, however, often fall short when a fast, noninvasive and specific diagnosis of fungal infection is necessary. Molecular imaging, especially using nuclear medicine-based techniques, aims to develop fungal-specific radiotracers that can be tested in preclinical models and eventually translated to human applications. In the last few decades, multiple radioligands have been developed and tested as potential fungal-specific tracers. These include radiolabeled peptides, antifungal drugs, siderophores, fungal-specific antibodies, and sugars. In this review, we provide an overview of the pros and cons of the available radiotracers. We also address the future prospects of fungal-specific imaging.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF INFECTIOUS DISEASES

ISSN

0022-1899

e-ISSN

1537-6613

Svazek periodika

228

Číslo periodika v rámci svazku

03.10.2023

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

"S259"-"S269"

Kód UT WoS článku

001093988600005

EID výsledku v databázi Scopus

2-s2.0-85173016617