The effect of COL5A1, GDF5 and PPARA genes on a movement screen and neuromuscular performance in adolescent team sport athletes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73596741" target="_blank" >RIV/61989592:15110/19:73596741 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15510/19:73596741

Výsledek na webu

<a href="https://insights.ovid.com/crossref?an=00124278-201908000-00003" target="_blank" >https://insights.ovid.com/crossref?an=00124278-201908000-00003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1519/JSC.0000000000003142" target="_blank" >10.1519/JSC.0000000000003142</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The effect of COL5A1, GDF5 and PPARA genes on a movement screen and neuromuscular performance in adolescent team sport athletes

Popis výsledku v původním jazyce

The risk of injury increases with adolescents’ chronological age and may be related to limited muscle function neuromuscular, genetic and biomechanical factors. The purpose of this study was to determine whether COL5A1, PPARA and GDF5 genes are associated with muscle functions and stretch shortening cycle performance in adolescent athletes. 146 youth players (14.4± 0.2 years) from various team sports (basketball n= 54, soccer n= 50, handball n= 32) underwent a manual test for muscle function, maturity estimation, functional bend test (FBT), passive straight leg raise test (SLR), leg stiffness test, test of reactive strength index (RSI), and gene sampling for COL5A1, PPARA and GDF5. The χ2 test did not showed any differences in allele or genotype frequency between participants before and after peak height velocity. MANOVA showed that COL5A1 rs12722 CT heterozygotes had worse score in FBT (p&lt; 0.001), worse score in SLR (p=0.003) and lower maturity offset (p= .029, only in females) than TT homozygotes. Male GDF5 rs143383 GG homozygotes showed better score in SLR than AA and AG genotypes (p= .003), and AA and AG genotypes in both sex had greater RSI than GG homozygotes (p= .016). The PPARA rs4253778 CC homozygotes had greater RSI than GG and GC genotypes (p= .004). The CT genotype in COL5A1 rs12722 is possible predictor of functional movements disruption in the posterior hip muscle chain, causing shortening in FBT and SLR which includes hamstrings function. CT genotype in COL5A1 rs12722 should be involved in programmes targeting hamstring and posterior hip muscle chain.

Název v anglickém jazyce

The effect of COL5A1, GDF5 and PPARA genes on a movement screen and neuromuscular performance in adolescent team sport athletes

Popis výsledku anglicky

The risk of injury increases with adolescents’ chronological age and may be related to limited muscle function neuromuscular, genetic and biomechanical factors. The purpose of this study was to determine whether COL5A1, PPARA and GDF5 genes are associated with muscle functions and stretch shortening cycle performance in adolescent athletes. 146 youth players (14.4± 0.2 years) from various team sports (basketball n= 54, soccer n= 50, handball n= 32) underwent a manual test for muscle function, maturity estimation, functional bend test (FBT), passive straight leg raise test (SLR), leg stiffness test, test of reactive strength index (RSI), and gene sampling for COL5A1, PPARA and GDF5. The χ2 test did not showed any differences in allele or genotype frequency between participants before and after peak height velocity. MANOVA showed that COL5A1 rs12722 CT heterozygotes had worse score in FBT (p&lt; 0.001), worse score in SLR (p=0.003) and lower maturity offset (p= .029, only in females) than TT homozygotes. Male GDF5 rs143383 GG homozygotes showed better score in SLR than AA and AG genotypes (p= .003), and AA and AG genotypes in both sex had greater RSI than GG homozygotes (p= .016). The PPARA rs4253778 CC homozygotes had greater RSI than GG and GC genotypes (p= .004). The CT genotype in COL5A1 rs12722 is possible predictor of functional movements disruption in the posterior hip muscle chain, causing shortening in FBT and SLR which includes hamstrings function. CT genotype in COL5A1 rs12722 should be involved in programmes targeting hamstring and posterior hip muscle chain.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30306 - Sport and fitness sciences

Projekt

<a href="/cs/project/GA16-13750S" target="_blank" >GA16-13750S: Kumulativní efekt únavy na neuromuskulární řízení kolene a riziko zranění u mladých sportovců během růstu a zrání</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF STRENGTH AND CONDITIONING RESEARCH

ISSN

1064-8011

e-ISSN

—

Svazek periodika

33

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

2057-2065

Kód UT WoS článku

000480708700005

EID výsledku v databázi Scopus

2-s2.0-85076868331