Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73597032" target="_blank" >RIV/61989592:15110/19:73597032 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/19:73597032

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S0223523419306993?token=B9C3612B47A2D55311625A16D10B89D3596D346B6C3902ECBC9A3D908AC84A3ED08D4775520A4BC87E1D34F82B5B049C" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0223523419306993?token=B9C3612B47A2D55311625A16D10B89D3596D346B6C3902ECBC9A3D908AC84A3ED08D4775520A4BC87E1D34F82B5B049C</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejmech.2019.111569" target="_blank" >10.1016/j.ejmech.2019.111569</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases

Popis výsledku v původním jazyce

This article provides an overview of compounds based on imidazo[1,2-a]pyridine, imidazo[1,5-a]pyridine, imidazo[4,5-b]pyridine and imidazo[4,5-c]pyridine scaffolds, which act as potent ligands of diverse molecular targets localized in the central nervous system. A literature survey revealed that various imidazopyridines can be powerful modulators of several diseases associated with CNS dysfunction including Alzheimer’s disease, Parkinson’s disease, schizophrenia, depression or sleeping disorders. A description of target enzymes (e.g., -secretase, γ-secretase, fatty acid amide hydrolase – FAAH, leucine-rich repeat kinase 2 – LRRK2) and selected receptors (e.g., GABA-A, histamine H3, serotonin 5-HT3, 5-HT4, 5-HT6, dopamine D4, adenosine A2A, orexin receptor), modes of action of imidazopyridine-based ligands and their therapeutic importance is discussed.

Název v anglickém jazyce

Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases

Popis výsledku anglicky

This article provides an overview of compounds based on imidazo[1,2-a]pyridine, imidazo[1,5-a]pyridine, imidazo[4,5-b]pyridine and imidazo[4,5-c]pyridine scaffolds, which act as potent ligands of diverse molecular targets localized in the central nervous system. A literature survey revealed that various imidazopyridines can be powerful modulators of several diseases associated with CNS dysfunction including Alzheimer’s disease, Parkinson’s disease, schizophrenia, depression or sleeping disorders. A description of target enzymes (e.g., -secretase, γ-secretase, fatty acid amide hydrolase – FAAH, leucine-rich repeat kinase 2 – LRRK2) and selected receptors (e.g., GABA-A, histamine H3, serotonin 5-HT3, 5-HT4, 5-HT6, dopamine D4, adenosine A2A, orexin receptor), modes of action of imidazopyridine-based ligands and their therapeutic importance is discussed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10401 - Organic chemistry

Projekt

<a href="/cs/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molekulární, buněčný a klinický přístup ke zdravému stárnutí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

ISSN

0223-5234

e-ISSN

—

Svazek periodika

181

Číslo periodika v rámci svazku

NA

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

25

Strana od-do

—

Kód UT WoS článku

000493211900004

EID výsledku v databázi Scopus

2-s2.0-85070331086