Non-homogeneous dissolution of drug affects the quality of parenteral treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73600910" target="_blank" >RIV/61989592:15110/19:73600910 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.researchgate.net/publication/332765575_NON-HOMOGENEOUS_DISSOLUTION_OF_DRUG_AFFECTS_THE_QUALITY_OF_PARENTERAL_TREATMENT" target="_blank" >https://www.researchgate.net/publication/332765575_NON-HOMOGENEOUS_DISSOLUTION_OF_DRUG_AFFECTS_THE_QUALITY_OF_PARENTERAL_TREATMENT</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.32383/appdr/99297" target="_blank" >10.32383/appdr/99297</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Non-homogeneous dissolution of drug affects the quality of parenteral treatment

Popis výsledku v původním jazyce

Intravenous administration of the drugs poses risks as treatment failure or higher incidence ofunwanted effects. There are many critical steps in the preparation of infusion. The aim of this experimentalstudy was to evaluate the effect of careful or careless infusion preparation on meropenem concentration in theinfusion. Three different ways for the preparation of the infusion solution were compared. The first third of thebags were inverted ten times after meropenem addition. The second third of the bags were hung up aftermeropenem addition without shaking, and the last third of the bags were first hang up on the holder and thenthe antibiotic was added. Samples of meropenem were collected regularly and were used for the subsequentHPLC analysis. There are significant differences in meropenem concentration depending on the preparation.The variation of meropenem concentration is significantly higher where inadequate homogenization was used.Our results showed that proper inverting of the infusion container provides the homogenous infusion solution.Late drug addition or inadequate mixing may have a clinical impact on the given dose, especially in continu-ously administered drugs

Název v anglickém jazyce

Non-homogeneous dissolution of drug affects the quality of parenteral treatment

Popis výsledku anglicky

Intravenous administration of the drugs poses risks as treatment failure or higher incidence ofunwanted effects. There are many critical steps in the preparation of infusion. The aim of this experimentalstudy was to evaluate the effect of careful or careless infusion preparation on meropenem concentration in theinfusion. Three different ways for the preparation of the infusion solution were compared. The first third of thebags were inverted ten times after meropenem addition. The second third of the bags were hung up aftermeropenem addition without shaking, and the last third of the bags were first hang up on the holder and thenthe antibiotic was added. Samples of meropenem were collected regularly and were used for the subsequentHPLC analysis. There are significant differences in meropenem concentration depending on the preparation.The variation of meropenem concentration is significantly higher where inadequate homogenization was used.Our results showed that proper inverting of the infusion container provides the homogenous infusion solution.Late drug addition or inadequate mixing may have a clinical impact on the given dose, especially in continu-ously administered drugs

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACTA POLONIAE PHARMACEUTICA

ISSN

0001-6837

e-ISSN

—

Svazek periodika

76

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

5

Strana od-do

323-327

Kód UT WoS článku

000468126500014

EID výsledku v databázi Scopus

2-s2.0-85068644331