Deep Brain Stimulation Effects on Gait Pattern in Advanced Parkinson’s Disease Patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73603280" target="_blank" >RIV/61989592:15110/20:73603280 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/20:N0000128

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fnins.2020.00814/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnins.2020.00814/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnins.2020.00814" target="_blank" >10.3389/fnins.2020.00814</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Deep Brain Stimulation Effects on Gait Pattern in Advanced Parkinson’s Disease Patients

Popis výsledku v původním jazyce

Background Gait disturbance accompanies many neurodegenerative diseases; it is characteristic for Parkinson&apos;s disease (PD). Treatment of advanced PD often includes deep brain stimulation (DBS) of the subthalamic nucleus. Regarding gait, previous studies have reported non-significant or conflicting results, possibly related to methodological limitations. Objective The objective of this prospective study was to assess the effects of DBS on biomechanical parameters of gait in patients with PD. Methods Twenty-one patients with advanced PD participated in this prospective study. Gait was examined in all patients using the Zebris FDM-T pressure-sensitive treadmill (Isny, Germany) before DBS implantation and after surgery immediately, further immediately after the start of neurostimulation, and 3 months after neurostimulator activation. We assessed spontaneous gait on a moving treadmill at different speeds. Step length, stance phase of both lower limbs, double-stance phase, and cadence were evaluated. Results In this study, step length increased, allowing the cadence to decrease. Double-stance phase duration, that is, the most sensitive parameter of gait quality and unsteadiness, was reduced, in gait at a speed of 4.5 km/h and in the narrow-based gaits at 1 km/h (tandem gait), which demonstrates improvement. Conclusion This study suggests positive effects of DBS treatment on gait in PD patients. Improvement was observed in several biomechanical parameters of gait.

Název v anglickém jazyce

Deep Brain Stimulation Effects on Gait Pattern in Advanced Parkinson’s Disease Patients

Popis výsledku anglicky

Background Gait disturbance accompanies many neurodegenerative diseases; it is characteristic for Parkinson&apos;s disease (PD). Treatment of advanced PD often includes deep brain stimulation (DBS) of the subthalamic nucleus. Regarding gait, previous studies have reported non-significant or conflicting results, possibly related to methodological limitations. Objective The objective of this prospective study was to assess the effects of DBS on biomechanical parameters of gait in patients with PD. Methods Twenty-one patients with advanced PD participated in this prospective study. Gait was examined in all patients using the Zebris FDM-T pressure-sensitive treadmill (Isny, Germany) before DBS implantation and after surgery immediately, further immediately after the start of neurostimulation, and 3 months after neurostimulator activation. We assessed spontaneous gait on a moving treadmill at different speeds. Step length, stance phase of both lower limbs, double-stance phase, and cadence were evaluated. Results In this study, step length increased, allowing the cadence to decrease. Double-stance phase duration, that is, the most sensitive parameter of gait quality and unsteadiness, was reduced, in gait at a speed of 4.5 km/h and in the narrow-based gaits at 1 km/h (tandem gait), which demonstrates improvement. Conclusion This study suggests positive effects of DBS treatment on gait in PD patients. Improvement was observed in several biomechanical parameters of gait.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Neuroscience

ISSN

1662-453X

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

August 2020

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

"'814(1)'"-"'814(9)'"

Kód UT WoS článku

000566222800001

EID výsledku v databázi Scopus

2-s2.0-85090009062