New aromatic 6-substituted 2 '-deoxy-9-(beta)-D-ribofuranosylpurine derivatives as potential plant growth regulators

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F20%3A73604703" target="_blank" >RIV/61989592:15110/20:73604703 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/20:73604703

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0968089619317304" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0968089619317304</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bmc.2019.115230" target="_blank" >10.1016/j.bmc.2019.115230</a>

Jazyk výsledku

angličtina

Název v původním jazyce

New aromatic 6-substituted 2 '-deoxy-9-(beta)-D-ribofuranosylpurine derivatives as potential plant growth regulators

Popis výsledku v původním jazyce

Cytokinins are naturally occurring substances that act as plant growth regulators promoting plant growth and development, including shoot initiation and branching, and also affecting apical dominance and leaf senescence. Aromatic cytokinin 6-benzylaminopurine (BAP) has been widely used in micropropagation systems and biotechnology. However, its 9-glucoside (BAP9G) accumulates in explants, causing root inhibition and growth heterogenity. To overcome BAP disadvantages, a series of ring-substituted 2&apos;-deoxy-9-(beta)-D-ribofuranosylpurine derivatives was prepared and examined in different classical cytokinin bioassays. Amaranthus, senescence and tobacco callus bioassays were employed to provide details of cytokinin activity of 2&apos;-deoxy-9-(beta)-D-ribosides compared to their respective free bases and ribosides. The prepared derivatives were also tested for their recognition by cytokinin receptors of Arabidopsis thaliana AHK3 and CRE1/AHK4. The ability of aromatic N-6-substituted adenine-2&apos;-deoxy-9-(beta)-D-ribosides to promote plant growth and delay senescence was increased considerably and, in contrast to BAP, no loss of cytokinin activity at higher concentrations was observed. The presence of a 2&apos;-deoxyribosyl moiety at the N9-position led to an increase in cytokinin activities in comparison to the free bases and ribosides. The antioxidant capacity, cytotoxicity and effect on the MHV-68 gammaherpesvirus strain were also examined.

Název v anglickém jazyce

New aromatic 6-substituted 2 '-deoxy-9-(beta)-D-ribofuranosylpurine derivatives as potential plant growth regulators

Popis výsledku anglicky

Cytokinins are naturally occurring substances that act as plant growth regulators promoting plant growth and development, including shoot initiation and branching, and also affecting apical dominance and leaf senescence. Aromatic cytokinin 6-benzylaminopurine (BAP) has been widely used in micropropagation systems and biotechnology. However, its 9-glucoside (BAP9G) accumulates in explants, causing root inhibition and growth heterogenity. To overcome BAP disadvantages, a series of ring-substituted 2&apos;-deoxy-9-(beta)-D-ribofuranosylpurine derivatives was prepared and examined in different classical cytokinin bioassays. Amaranthus, senescence and tobacco callus bioassays were employed to provide details of cytokinin activity of 2&apos;-deoxy-9-(beta)-D-ribosides compared to their respective free bases and ribosides. The prepared derivatives were also tested for their recognition by cytokinin receptors of Arabidopsis thaliana AHK3 and CRE1/AHK4. The ability of aromatic N-6-substituted adenine-2&apos;-deoxy-9-(beta)-D-ribosides to promote plant growth and delay senescence was increased considerably and, in contrast to BAP, no loss of cytokinin activity at higher concentrations was observed. The presence of a 2&apos;-deoxyribosyl moiety at the N9-position led to an increase in cytokinin activities in comparison to the free bases and ribosides. The antioxidant capacity, cytotoxicity and effect on the MHV-68 gammaherpesvirus strain were also examined.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10611 - Plant sciences, botany

Projekt

<a href="/cs/project/EF16_019%2F0000827" target="_blank" >EF16_019/0000827: Rostliny jako prostředek udržitelného globálního rozvoje</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BIOORGANIC &amp; MEDICINAL CHEMISTRY LETTERS

ISSN

0960-894X

e-ISSN

—

Svazek periodika

28

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

15

Strana od-do

"115230-1"-"115230-15"

Kód UT WoS článku

000504647600008

EID výsledku v databázi Scopus

2-s2.0-85077001027