The expression of selected fibrotic factors in COPD and asthma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F22%3A73616835" target="_blank" >RIV/61989592:15110/22:73616835 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/22:10157752

Výsledek na webu

<a href="http://www.elis.sk/download_file.php?product_id=7752&session_id=gdg3jfsbltti83nvne2tk4e404" target="_blank" >http://www.elis.sk/download_file.php?product_id=7752&session_id=gdg3jfsbltti83nvne2tk4e404</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2022_112" target="_blank" >10.4149/BLL_2022_112</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The expression of selected fibrotic factors in COPD and asthma

Popis výsledku v původním jazyce

BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) and asthma are associated with chronic inflammation leading to airway obstruction and remodelling. There is little information on possible differences in the TGFB signalling pathway in the pathologies compared to less severe chronic bronchitis without airway obstruction.AIM: To assess the expression of the selected TGFB signalling pathway-associated genes in the pathologies.METHOD: RT-PCR was used to quantify the mRNAs in bronchoalveolar cells obtained from the Czech patients with chronic bronchitis (n = 26), COPD (n = 22), asthmatic (n = 14) patients.RESULTS: There was no difference in the BAL cell expression of TGFB1-3, TGFBR1-2, SMAD2,4,5, and 7 between our patients with COPD and those with chronic bronchitis. The expressions were also similar in the patients with asthma and chronic bronchitis. There was no difference between the patients with asthma and COPD. CONCLUSION: Although we observed no differences in our patients, other studies should investigate the genes and their possible correlation with advanced airway obstruction and emphysematous changes (Tab. 2, Fig. 3, Ref. 27). Text in PDF www.elis.sk

Název v anglickém jazyce

The expression of selected fibrotic factors in COPD and asthma

Popis výsledku anglicky

BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) and asthma are associated with chronic inflammation leading to airway obstruction and remodelling. There is little information on possible differences in the TGFB signalling pathway in the pathologies compared to less severe chronic bronchitis without airway obstruction.AIM: To assess the expression of the selected TGFB signalling pathway-associated genes in the pathologies.METHOD: RT-PCR was used to quantify the mRNAs in bronchoalveolar cells obtained from the Czech patients with chronic bronchitis (n = 26), COPD (n = 22), asthmatic (n = 14) patients.RESULTS: There was no difference in the BAL cell expression of TGFB1-3, TGFBR1-2, SMAD2,4,5, and 7 between our patients with COPD and those with chronic bronchitis. The expressions were also similar in the patients with asthma and chronic bronchitis. There was no difference between the patients with asthma and COPD. CONCLUSION: Although we observed no differences in our patients, other studies should investigate the genes and their possible correlation with advanced airway obstruction and emphysematous changes (Tab. 2, Fig. 3, Ref. 27). Text in PDF www.elis.sk

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30218 - General and internal medicine

Projekt

<a href="/cs/project/EF16_019%2F0000868" target="_blank" >EF16_019/0000868: Molekulární, buněčný a klinický přístup ke zdravému stárnutí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislava Medical Journal

ISSN

0006-9248

e-ISSN

1336-0345

Svazek periodika

123

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

5

Strana od-do

705-709

Kód UT WoS článku

000858637000002

EID výsledku v databázi Scopus

2-s2.0-85138136093