3D Printing and Electrospinning of Drug- and Graphene-Enhanced Polycaprolactone Scaffolds for Osteochondral Nasal Repair

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F25%3A73633889" target="_blank" >RIV/61989592:15110/25:73633889 - isvavai.cz</a>

Výsledek na webu

<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC12028827/pdf/materials-18-01826.pdf" target="_blank" >https://pmc.ncbi.nlm.nih.gov/articles/PMC12028827/pdf/materials-18-01826.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ma18081826" target="_blank" >10.3390/ma18081826</a>

Jazyk výsledku

angličtina

Název v původním jazyce

3D Printing and Electrospinning of Drug- and Graphene-Enhanced Polycaprolactone Scaffolds for Osteochondral Nasal Repair

Popis výsledku v původním jazyce

A novel bi-layered scaffold, obtained via 3D printing and electrospinning, was designed to improve osteochondral region reconstruction. The upper electrospun membrane will act as a barrier against unwanted tissue infiltration, while the lower 3D-printed layer will provide a porous structure for tissue ingrowth. Graphene was integrated into the scaffold for its antibacterial properties, and the drug Osteogenon® (OST) was added to promote bone tissue regeneration. The composite scaffolds were subjected to comprehensive physical, thermal, and mechanical evaluations. Additionally, their biological functionality was assessed by means of NHAC-kn cells. The 0.5% graphene addition to PCL significantly increased strain at break, enhancing the material ductility. GNP also acted as an effective nucleating agent, raising crystallization temperatures and supporting mineralization. The high surface area of graphene facilitated rapid apatite formation by attracting calcium and phosphate ions. This was confirmed by FTIR, µCT and SEM analyses, which highlighted the positive impact of graphene on mineral deposition. The synergistic interaction between graphene nanoplatelets and Osteogenon® created a bioactive environment that enhanced cell adhesion and proliferation, and promoted superior apatite formation. These findings highlight the scaffold&apos;s potential as a promising biomaterial for osteochondral repair and regenerative medicine.

Název v anglickém jazyce

3D Printing and Electrospinning of Drug- and Graphene-Enhanced Polycaprolactone Scaffolds for Osteochondral Nasal Repair

Popis výsledku anglicky

A novel bi-layered scaffold, obtained via 3D printing and electrospinning, was designed to improve osteochondral region reconstruction. The upper electrospun membrane will act as a barrier against unwanted tissue infiltration, while the lower 3D-printed layer will provide a porous structure for tissue ingrowth. Graphene was integrated into the scaffold for its antibacterial properties, and the drug Osteogenon® (OST) was added to promote bone tissue regeneration. The composite scaffolds were subjected to comprehensive physical, thermal, and mechanical evaluations. Additionally, their biological functionality was assessed by means of NHAC-kn cells. The 0.5% graphene addition to PCL significantly increased strain at break, enhancing the material ductility. GNP also acted as an effective nucleating agent, raising crystallization temperatures and supporting mineralization. The high surface area of graphene facilitated rapid apatite formation by attracting calcium and phosphate ions. This was confirmed by FTIR, µCT and SEM analyses, which highlighted the positive impact of graphene on mineral deposition. The synergistic interaction between graphene nanoplatelets and Osteogenon® created a bioactive environment that enhanced cell adhesion and proliferation, and promoted superior apatite formation. These findings highlight the scaffold&apos;s potential as a promising biomaterial for osteochondral repair and regenerative medicine.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/GF21-45449L" target="_blank" >GF21-45449L: Funkční gradientové materiály připravené metodou 3D a 4D tisku pro regeneraci osteochondrálních defektů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials

ISSN

1996-1944

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

19

Strana od-do

1826

Kód UT WoS článku

001475324700001

EID výsledku v databázi Scopus

2-s2.0-105003746269