Estimation of partition coefficients by MEKC - Part I: Potential pharmaceuticals based on 2-guinolone and 2-indolone

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F01%3A00001303" target="_blank" >RIV/61989592:15310/01:00001303 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Estimation of partition coefficients by MEKC - Part I: Potential pharmaceuticals based on 2-guinolone and 2-indolone

Popis výsledku v původním jazyce

The octanol-water partition coefficients of 18 potential pharmaceuticals derived from 2-quinolone and 2-indolone were measured by means of MEKC. Their values range from 2.2 to 4.7 (expressed in logarithmic form). The critical micelle concentration (CIVIC) of SIDS was determined conductometrically and the partial specific volumes of the micelles in the buffer (25 mM sodium borate, pH 9.5) were calculated from density data. The values were used for determination of the phase ratio and for estimation of the micelle-water (K-mw) and octanol water (K-ow) partition coefficients. Direct calculation of K-ow from the easily measurable capacity factors (le) gives results comparable with those laboriously determined from K-mw. Extrapolation of the micellar time from the set of migration times of alkylbenzene standards proved to be viable alternative to measurements using a marker.

Název v anglickém jazyce

Estimation of partition coefficients by MEKC - Part I: Potential pharmaceuticals based on 2-guinolone and 2-indolone

Popis výsledku anglicky

The octanol-water partition coefficients of 18 potential pharmaceuticals derived from 2-quinolone and 2-indolone were measured by means of MEKC. Their values range from 2.2 to 4.7 (expressed in logarithmic form). The critical micelle concentration (CIVIC) of SIDS was determined conductometrically and the partial specific volumes of the micelles in the buffer (25 mM sodium borate, pH 9.5) were calculated from density data. The values were used for determination of the phase ratio and for estimation of the micelle-water (K-mw) and octanol water (K-ow) partition coefficients. Direct calculation of K-ow from the easily measurable capacity factors (le) gives results comparable with those laboriously determined from K-mw. Extrapolation of the micellar time from the set of migration times of alkylbenzene standards proved to be viable alternative to measurements using a marker.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Separation Science

ISSN

1615-9314

e-ISSN

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Svazek periodika

24

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

723-728

Kód UT WoS článku

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EID výsledku v databázi Scopus

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