Antiproliferativní účinky nového inhibitoru CDK, olomoucinu II

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F04%3A00002152" target="_blank" >RIV/61989592:15310/04:00002152 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Antiproliferative activity of Olomoucine II, a novel cyclin-dependent kinase inhibitor

Popis výsledku v původním jazyce

Altered phosphorylation of cellular proteins stimulated an extensive search for protein kinase inhibitors as drugs. Cyclin-dependent kinases (CDKs), enzymes involved in diverse cellular processes, including cell division cycle, transcription, differentiation and apoptosis, are suitable targets of such inhibitors with potential application in cancer therapy1. One of the first reported specific CDK inhibitors, olomoucine, had became a leading compound of the development based on structure-activity relatioships, that led to the synthesis of roscovitine2 and olomoucine II (ref.3), respectively. Both derivatives show an enhanced CDK inhibitory activity, increased selectivity and antiproliferative activity. Moreover, roscovitine has been also shown to inducenuclear accumulation of tumour suppressor p53 and enhance p53-dependent transcription in human cancer cells4. The novel derivative olomoucine II inhibits CDKs more efficiently and causes cell cycle blocks at G1/S and G2/M transitions str

Název v anglickém jazyce

Antiproliferative activity of Olomoucine II, a novel cyclin-dependent kinase inhibitor

Popis výsledku anglicky

Altered phosphorylation of cellular proteins stimulated an extensive search for protein kinase inhibitors as drugs. Cyclin-dependent kinases (CDKs), enzymes involved in diverse cellular processes, including cell division cycle, transcription, differentiation and apoptosis, are suitable targets of such inhibitors with potential application in cancer therapy1. One of the first reported specific CDK inhibitors, olomoucine, had became a leading compound of the development based on structure-activity relatioships, that led to the synthesis of roscovitine2 and olomoucine II (ref.3), respectively. Both derivatives show an enhanced CDK inhibitory activity, increased selectivity and antiproliferative activity. Moreover, roscovitine has been also shown to inducenuclear accumulation of tumour suppressor p53 and enhance p53-dependent transcription in human cancer cells4. The novel derivative olomoucine II inhibits CDKs more efficiently and causes cell cycle blocks at G1/S and G2/M transitions str

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Universitatis Palackianae Olomucensis, Facultas Rerum Naturalium, Chemica

ISSN

0232-0061

e-ISSN

—

Svazek periodika

43

Číslo periodika v rámci svazku

Suppl.

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

278

Strana od-do

133

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—