Nové deriváty cytokininů pro zemědělství a medicínu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F04%3A00002278" target="_blank" >RIV/61989592:15310/04:00002278 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

New cytokinin derivatives for agriculture and medicine

Popis výsledku v původním jazyce

New series of cytokinins derived from 6-benzylaminopurine have been developed for agricultural and biotechnological applications. These compounds exhibit very high biological activities in different cytokinin bioassays. The methoxy and fluoro derivativesexhibited 2-10 times higher activity then trans-zeatin and expressed very positive antisenescent and morphogenetic properties in different in vitro cultures. Among aromatic cytokinin derivatives, we have discovered a compound, 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine, named "olomoucine" (OC), which specifically inhibits some cyclin-dependent kinases (CDKs) at micromolar concentration. The design and inhibitory activity of OC was further improved by modifications at positions 2, 6, and 9. This has led to development of specific CDK inhibitors like roscovitine, olomoucine II and purvalanol A, which display an enhanced inhibitory activity toward CDK1, a higher selectivity for some CDKs, an increased antimitotic activity at the

Název v anglickém jazyce

New cytokinin derivatives for agriculture and medicine

Popis výsledku anglicky

New series of cytokinins derived from 6-benzylaminopurine have been developed for agricultural and biotechnological applications. These compounds exhibit very high biological activities in different cytokinin bioassays. The methoxy and fluoro derivativesexhibited 2-10 times higher activity then trans-zeatin and expressed very positive antisenescent and morphogenetic properties in different in vitro cultures. Among aromatic cytokinin derivatives, we have discovered a compound, 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine, named "olomoucine" (OC), which specifically inhibits some cyclin-dependent kinases (CDKs) at micromolar concentration. The design and inhibitory activity of OC was further improved by modifications at positions 2, 6, and 9. This has led to development of specific CDK inhibitors like roscovitine, olomoucine II and purvalanol A, which display an enhanced inhibitory activity toward CDK1, a higher selectivity for some CDKs, an increased antimitotic activity at the

Druh

D - Stať ve sborníku

CEP obor

EF - Botanika

OECD FORD obor

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Projekt

<a href="/cs/project/GA522%2F01%2F0275" target="_blank" >GA522/01/0275: Studium nových cytokininových metabolitů v rostlinách: isolace, identifikace a biosyntéza</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

18th IPGSA conference, Conference Handbook

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

144

Strana od-do

76

Název nakladatele

Australian National University

Místo vydání

Canberra

Místo konání akce

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Datum konání akce

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Typ akce podle státní příslušnosti

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Kód UT WoS článku

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