Cytokinins in biotechnology and medicine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F03%3A00001597" target="_blank" >RIV/61989592:15310/03:00001597 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cytokinins in biotechnology and medicine

Popis výsledku v původním jazyce

New series of cytokinins derived from 6-benzylaminopurine (BAP) have been developed for agricultural and biotechnological applications. These compounds exhibit very high biological activities in different cytokinin bioassays. Preferentially, the methoxyand fluoro derivatives had 2-10 times higher activity then trans-zeatin and expressed very positive antisenescent and morphogenetic properties in different in vitro cultures of some horticulture species. These compounds have been recently identified as new natural cytokinins. Our research focused on the primary mechanism of action of plant hormones cytokinins in cell division cycle has showed that natural plant cytokinins are rather non-specific inhibitors of various protein kinases. Surprisingly, amongaromatic cytokinin derivatives, we have discovered a compound, 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine, named "olomoucine", which specifically inhibits some cyclin-dependent kinases (cdks) at micromolar concentration. One of

Název v anglickém jazyce

Cytokinins in biotechnology and medicine

Popis výsledku anglicky

New series of cytokinins derived from 6-benzylaminopurine (BAP) have been developed for agricultural and biotechnological applications. These compounds exhibit very high biological activities in different cytokinin bioassays. Preferentially, the methoxyand fluoro derivatives had 2-10 times higher activity then trans-zeatin and expressed very positive antisenescent and morphogenetic properties in different in vitro cultures of some horticulture species. These compounds have been recently identified as new natural cytokinins. Our research focused on the primary mechanism of action of plant hormones cytokinins in cell division cycle has showed that natural plant cytokinins are rather non-specific inhibitors of various protein kinases. Surprisingly, amongaromatic cytokinin derivatives, we have discovered a compound, 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine, named "olomoucine", which specifically inhibits some cyclin-dependent kinases (cdks) at micromolar concentration. One of

Druh

D - Stať ve sborníku

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA522%2F03%2F0323" target="_blank" >GA522/03/0323: Studium produkce biologicky aktivních látek řasami a sinicemi</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

2nd Symposium of the Croatian Society on Plant Physiology

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

200

Strana od-do

168

Název nakladatele

Coratian Biological Society

Místo vydání

Zagreb

Místo konání akce

Zagreb

Datum konání akce

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Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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