Platinum(II) and palladium(II) oxalato complexes involving N6-benzyladenine-based CDK-inhibitors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00010070" target="_blank" >RIV/61989592:15310/09:00010070 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Platinum(II) and palladium(II) oxalato complexes involving N6-benzyladenine-based CDK-inhibitors

Popis výsledku v původním jazyce

This work represents a continuation of our systematic research of transition metal complexes with N6-benzyadenine derivatives. It deals with synthesis, characterization and in vitro cytotoxicity of the platinum(II) and palldium(II) oxalato complexes of the general formula [Pt(L)2(ox)] and [Pd(L)2(ox)], where L stands for a molecule of the cyclin-dependent kinase (CDK) inhibitor of N6-benzyl-9-isopropyladenine moiety. The complexes have been synthesized by a reaction of K2[M(ox)2].2H2O (M = Pt or Pd) with two molar equivalents of the appropriate L organic compounds. The prepared complexes have been fully characterized by varied methods including multinuclear NMR spectroscopy and single-crystal X ray analysis. The geometry of complexes is square planar with tetra-coordinated central transition metal ion and PtN2O2/PdN2O2 donor set. Two L molecules are coordinated through N7 atoms of thein purine moieties. Some of the complexes have shown significant in vitro cytotoxic properties against

Název v anglickém jazyce

Platinum(II) and palladium(II) oxalato complexes involving N6-benzyladenine-based CDK-inhibitors

Popis výsledku anglicky

This work represents a continuation of our systematic research of transition metal complexes with N6-benzyadenine derivatives. It deals with synthesis, characterization and in vitro cytotoxicity of the platinum(II) and palldium(II) oxalato complexes of the general formula [Pt(L)2(ox)] and [Pd(L)2(ox)], where L stands for a molecule of the cyclin-dependent kinase (CDK) inhibitor of N6-benzyl-9-isopropyladenine moiety. The complexes have been synthesized by a reaction of K2[M(ox)2].2H2O (M = Pt or Pd) with two molar equivalents of the appropriate L organic compounds. The prepared complexes have been fully characterized by varied methods including multinuclear NMR spectroscopy and single-crystal X ray analysis. The geometry of complexes is square planar with tetra-coordinated central transition metal ion and PtN2O2/PdN2O2 donor set. Two L molecules are coordinated through N7 atoms of thein purine moieties. Some of the complexes have shown significant in vitro cytotoxic properties against

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Biological Inorganic Chemistry

ISSN

0949-8257

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

JP - Japonsko

Počet stran výsledku

12

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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