Analysis of chiral compounds using mass spectrometric approaches

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00010511" target="_blank" >RIV/61989592:15310/09:00010511 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of chiral compounds using mass spectrometric approaches

Popis výsledku v původním jazyce

Analysis of isomers is an important task of analytical chemistry. An unquestionable number of enzymes, factors, cofactors and also other biologically important compounds are isomeric. One of the most interesting groups of isomers is the group of opticalisomers. Chiral analysis is generally based on applications of separation techniques or less commonly; it is based on spectroscopic approaches. Mass spectrometry can be labeled as an interesting alternative. Several mass spectrometric methods that are able to handle enantiomeric discriminations were developed, but most of them have only one of the potentially strong approaches. This method is based on a formation of trimer diastereoisomers that are composed of analyte (one ligand), reference (2 ligands), and all three ligands are coordinated by selected bivalent metal. These trimeric clusters are generated in the ion source (usually electrospray, but nano-electrospray or DESI can be used as well). Essentially, clusters can dissociate us

Název v anglickém jazyce

Analysis of chiral compounds using mass spectrometric approaches

Popis výsledku anglicky

Analysis of isomers is an important task of analytical chemistry. An unquestionable number of enzymes, factors, cofactors and also other biologically important compounds are isomeric. One of the most interesting groups of isomers is the group of opticalisomers. Chiral analysis is generally based on applications of separation techniques or less commonly; it is based on spectroscopic approaches. Mass spectrometry can be labeled as an interesting alternative. Several mass spectrometric methods that are able to handle enantiomeric discriminations were developed, but most of them have only one of the potentially strong approaches. This method is based on a formation of trimer diastereoisomers that are composed of analyte (one ligand), reference (2 ligands), and all three ligands are coordinated by selected bivalent metal. These trimeric clusters are generated in the ion source (usually electrospray, but nano-electrospray or DESI can be used as well). Essentially, clusters can dissociate us

Druh

O - Ostatní výsledky

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů