Aminoaldehydes: reactive products of polyamine degradation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00010913" target="_blank" >RIV/61989592:15310/09:00010913 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Aminoaldehydes: reactive products of polyamine degradation

Popis výsledku v původním jazyce

The oxidative degradation of diamines and polyamines catalyzed by amine oxidases produces ?-aminoaldehydes and hydrogen peroxide. ?-Aminoaldehydes may also be produced from their precursors nonoxidatively by a pyridoxal-phosphate dependent aminotransferase reaction. 3-Aminopropionaldehyde and 4-aminobutyraldehyde belong to the best substrates of NAD(P)+-dependent aminoaldehyde dehydrogenase. In this way they are oxidized to ?-alanine and 4-aminobutyric acid. 4-Aminobutyraldehyde and 5-aminovaleraldehydespontaneously cyclize to 1-pyrroline and 1-piperideine, respectively. The heterocycles are subsequently utilized in the production of several types of alkaloids. 4-Aminobutyraldehyde has recently been identified as the precursor of another kind of secondary metabolite, 2-acetyl-1-pyrroline, causing fragrance in certain rice varieties. 3-Aminopropionaldehyde is known as a potent cytotoxin. It is associated with certain diseases like cerebral ischemia and stroke.

Název v anglickém jazyce

Aminoaldehydes: reactive products of polyamine degradation

Popis výsledku anglicky

The oxidative degradation of diamines and polyamines catalyzed by amine oxidases produces ?-aminoaldehydes and hydrogen peroxide. ?-Aminoaldehydes may also be produced from their precursors nonoxidatively by a pyridoxal-phosphate dependent aminotransferase reaction. 3-Aminopropionaldehyde and 4-aminobutyraldehyde belong to the best substrates of NAD(P)+-dependent aminoaldehyde dehydrogenase. In this way they are oxidized to ?-alanine and 4-aminobutyric acid. 4-Aminobutyraldehyde and 5-aminovaleraldehydespontaneously cyclize to 1-pyrroline and 1-piperideine, respectively. The heterocycles are subsequently utilized in the production of several types of alkaloids. 4-Aminobutyraldehyde has recently been identified as the precursor of another kind of secondary metabolite, 2-acetyl-1-pyrroline, causing fragrance in certain rice varieties. 3-Aminopropionaldehyde is known as a potent cytotoxin. It is associated with certain diseases like cerebral ischemia and stroke.

Druh

C - Kapitola v odborné knize

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA522%2F08%2F0555" target="_blank" >GA522/08/0555: Strukturně-funkční charakterizace oxidoreduktas působících na dusíkaté regulační látky v rostlinách</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Biologically Active Amines and Related Enzymes? Biochemical, Physiological and Clinical Aspects (Toninello A., ed.)

ISBN

978-81-7895-433-2

Počet stran výsledku

24

Strana od-do

—

Počet stran knihy

300

Název nakladatele

Research Signpost, Transworld Research Network

Místo vydání

Kerala, India

Kód UT WoS kapitoly

—