Palladium(II) oxalato complexes involving N6-(benzyl)-9-isopropyladenine-based N-donor carrier ligands: Synthesis, general properties, H-1, C-13 and N-15{H-1} NMR characterization and in vitro cytotoxicity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F10%3A10213241" target="_blank" >RIV/61989592:15310/10:10213241 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Palladium(II) oxalato complexes involving N6-(benzyl)-9-isopropyladenine-based N-donor carrier ligands: Synthesis, general properties, H-1, C-13 and N-15{H-1} NMR characterization and in vitro cytotoxicity

Popis výsledku v původním jazyce

A series of seven palladium(II) oxalato (ox) complexes of the general formula [Pd(ox)(L1-7)(2)].nH(2)O (1-7; n = 0 for 4, 5 and 7, (3)/(4) for 1 and 2, 1 for 6, and 3 for 3) has been prepared. The compounds were characterized by elemental analysis, IR, Raman, H-1, C-13 and N-15{H-1} NMR spectroscopy, ESI+ mass spectrometry, molar conductivity and TG/DTA thermal analysis. The geometry of [Pd(ox)(L-2)(2)] (2) was optimized on the B3LYP/6-311G*/LANL2DZ level of theory. The complexes 4-7 represent the firstpalladium(II) oxalato complexes with a PdN2O2 donor set, which involve highly potent purine-based cyclin-dependent kinase (CDK) inhibitors (L4-7) as carrier N-donor ligands. The selected complexes 1, 3-5 and 7 were tested by an MTT assay for their in vitro cytotoxic activity against human osteosarcoma (HOS) cancer cell line.

Název v anglickém jazyce

Palladium(II) oxalato complexes involving N6-(benzyl)-9-isopropyladenine-based N-donor carrier ligands: Synthesis, general properties, H-1, C-13 and N-15{H-1} NMR characterization and in vitro cytotoxicity

Popis výsledku anglicky

A series of seven palladium(II) oxalato (ox) complexes of the general formula [Pd(ox)(L1-7)(2)].nH(2)O (1-7; n = 0 for 4, 5 and 7, (3)/(4) for 1 and 2, 1 for 6, and 3 for 3) has been prepared. The compounds were characterized by elemental analysis, IR, Raman, H-1, C-13 and N-15{H-1} NMR spectroscopy, ESI+ mass spectrometry, molar conductivity and TG/DTA thermal analysis. The geometry of [Pd(ox)(L-2)(2)] (2) was optimized on the B3LYP/6-311G*/LANL2DZ level of theory. The complexes 4-7 represent the firstpalladium(II) oxalato complexes with a PdN2O2 donor set, which involve highly potent purine-based cyclin-dependent kinase (CDK) inhibitors (L4-7) as carrier N-donor ligands. The selected complexes 1, 3-5 and 7 were tested by an MTT assay for their in vitro cytotoxic activity against human osteosarcoma (HOS) cancer cell line.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganica Chimica Acta

ISSN

0020-1693

e-ISSN

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Svazek periodika

363

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000276190300021

EID výsledku v databázi Scopus

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