Semisynthetic Lupane Triterpenes with Cytotoxic Activity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F10%3A10215489" target="_blank" >RIV/61989592:15310/10:10215489 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/10:00355519 RIV/61388963:_____/10:00355519

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Semisynthetic Lupane Triterpenes with Cytotoxic Activity

Popis výsledku v původním jazyce

Lupane compounds occupy an unique position among cytotoxic triterpenoids. In 1976, the cytotoxic effect of the extract of Vauquelinia corymbosa against the lymphocytic leukemia cell line P-388 had already been described. Betulinic acid was subsequently recognized as an active component of this extract. A few years later, its cytotoxic activity (IC50 value of approximately 0.5-1.5 g/mL) on the human melanoma cell line MEL-1 was reported. Since then, interest in this acid and its derivatives has been growing, especially within the pharmaceutical industry. Several years after the publication of the article by Pisha, a new work was published on a group of semisynthetic derivatives of betulin and betulinic acid called betulinines, with significant anticancer effects against a range of tumor cell lines of different histogenetic origin, including multidrug resistant cell types

Název v anglickém jazyce

Semisynthetic Lupane Triterpenes with Cytotoxic Activity

Popis výsledku anglicky

Lupane compounds occupy an unique position among cytotoxic triterpenoids. In 1976, the cytotoxic effect of the extract of Vauquelinia corymbosa against the lymphocytic leukemia cell line P-388 had already been described. Betulinic acid was subsequently recognized as an active component of this extract. A few years later, its cytotoxic activity (IC50 value of approximately 0.5-1.5 g/mL) on the human melanoma cell line MEL-1 was reported. Since then, interest in this acid and its derivatives has been growing, especially within the pharmaceutical industry. Several years after the publication of the article by Pisha, a new work was published on a group of semisynthetic derivatives of betulin and betulinic acid called betulinines, with significant anticancer effects against a range of tumor cell lines of different histogenetic origin, including multidrug resistant cell types

Druh

C - Kapitola v odborné knize

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Pentacyclic Triterpenes as Promising Agents in Cancer

ISBN

978-1-60876-973-5

Počet stran výsledku

31

Strana od-do

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Počet stran knihy

316

Název nakladatele

Nova Science Publishers, USA

Místo vydání

Hauppauge NY

Kód UT WoS kapitoly

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