Anticancer Activities of Brassinosteroids
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33119849" target="_blank" >RIV/61989592:15310/12:33119849 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61989592:15110/12:33119849 RIV/61389030:_____/12:00387440
Výsledek na webu
<a href="http://dx.doi.org/10.2174/97816080529811120101" target="_blank" >http://dx.doi.org/10.2174/97816080529811120101</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/97816080529811120101" target="_blank" >10.2174/97816080529811120101</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Anticancer Activities of Brassinosteroids
Popis výsledku v původním jazyce
Molecular and cellular effects of two groups of antiproliferative agents, natural brassinosteroids (BRs) and their synthetic derivatives, were examined in different human cancer cell lines and in primary endothelial cells in vitro. Natural and syntheticBRs caused growth inhibition, cell cycle arrest and initiation of apoptosis in many different cancer cell lines. The inhibition of proliferation and migration of human endothelial cells by BRs was demonstrated and evidences were obtained that BRs initiate cell death by apoptosis. And, analogues of BRs were found to be more effective than natural BRs. Observed inhibition of migration and tube formation demonstrated the antiangiogenic activity of BRs. These findings indicate a potential use of BRs in theprevention of metastasis development. Investigation of the mechanisms of action of BRs in human cancer and endothelial cells using cellular and molecular techniques indicated the possible involvement of steroid receptors in BR action. How
Název v anglickém jazyce
Anticancer Activities of Brassinosteroids
Popis výsledku anglicky
Molecular and cellular effects of two groups of antiproliferative agents, natural brassinosteroids (BRs) and their synthetic derivatives, were examined in different human cancer cell lines and in primary endothelial cells in vitro. Natural and syntheticBRs caused growth inhibition, cell cycle arrest and initiation of apoptosis in many different cancer cell lines. The inhibition of proliferation and migration of human endothelial cells by BRs was demonstrated and evidences were obtained that BRs initiate cell death by apoptosis. And, analogues of BRs were found to be more effective than natural BRs. Observed inhibition of migration and tube formation demonstrated the antiangiogenic activity of BRs. These findings indicate a potential use of BRs in theprevention of metastasis development. Investigation of the mechanisms of action of BRs in human cancer and endothelial cells using cellular and molecular techniques indicated the possible involvement of steroid receptors in BR action. How
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
EF - Botanika
OECD FORD obor
—
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
Brassinosteroids: Practical Applications in Agriculture and Human Health
ISBN
978-1-60805-298-1
Počet stran výsledku
10
Strana od-do
84-93
Počet stran knihy
96
Název nakladatele
Bentham Science Publishers
Místo vydání
Spojené arabské emiráty
Kód UT WoS kapitoly
—