Overcoming instability and low solubility of new cytostatic compounds: A comparsion of two approaches

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33141479" target="_blank" >RIV/61989592:15310/12:33141479 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ejpb.2011.11.016" target="_blank" >http://dx.doi.org/10.1016/j.ejpb.2011.11.016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejpb.2011.11.016" target="_blank" >10.1016/j.ejpb.2011.11.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Overcoming instability and low solubility of new cytostatic compounds: A comparsion of two approaches

Popis výsledku v původním jazyce

The pharmaceutical use of some 3-hydroxyquinolinone derivatives with high cytotoxic and cytostatic activities (under in vitro conditions) as well as potential immunosuppressive properties is seriously limited by their low solubility in water accompaniedby instability in oxidative environment, like physiological fluids. In an attempt to improve the bioavailability and the stability of four of these derivatives, we propose here two different approaches: complexation with beta-cyclodextrin derivatives andincorporation of these substances inside antioxidant micelles. The comparison of the two different methods is the focus of this work, as well as the investigation of some physicochemical properties of the micellar aqueous dispersions. Antioxidant micellar dispersions appear to be suitable for increasing the apparent solubility and stability for all the compounds studied, most probably because of the antioxidant activity of the specific surfactant used, combined with the low amount of wa

Název v anglickém jazyce

Overcoming instability and low solubility of new cytostatic compounds: A comparsion of two approaches

Popis výsledku anglicky

The pharmaceutical use of some 3-hydroxyquinolinone derivatives with high cytotoxic and cytostatic activities (under in vitro conditions) as well as potential immunosuppressive properties is seriously limited by their low solubility in water accompaniedby instability in oxidative environment, like physiological fluids. In an attempt to improve the bioavailability and the stability of four of these derivatives, we propose here two different approaches: complexation with beta-cyclodextrin derivatives andincorporation of these substances inside antioxidant micelles. The comparison of the two different methods is the focus of this work, as well as the investigation of some physicochemical properties of the micellar aqueous dispersions. Antioxidant micellar dispersions appear to be suitable for increasing the apparent solubility and stability for all the compounds studied, most probably because of the antioxidant activity of the specific surfactant used, combined with the low amount of wa

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Pharmaceutics and Biopharmaceutics

ISSN

0939-6411

e-ISSN

—

Svazek periodika

80

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

657-662

Kód UT WoS článku

000302930200022

EID výsledku v databázi Scopus

—