Lipid Bilayer Membrane Affinity Rationalizes Inhibition of Lipid Peroxidation by a Natural Lignan Antioxidant

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33145676" target="_blank" >RIV/61989592:15310/13:33145676 - isvavai.cz</a>

Výsledek na webu

<a href="http://pubs.acs.org/doi/abs/10.1021/jp3127829" target="_blank" >http://pubs.acs.org/doi/abs/10.1021/jp3127829</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/jp3127829" target="_blank" >10.1021/jp3127829</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lipid Bilayer Membrane Affinity Rationalizes Inhibition of Lipid Peroxidation by a Natural Lignan Antioxidant

Popis výsledku v původním jazyce

Lipid peroxidation is a degenerative oxidative process that modifies the structure of membranes, influencing their :biological functions.,Lignans, natural polyphenolic antioxidants widely distributed in plants, can prevent this membrane damage by free radical scavenging. Here,: we rationalize the difference in lipid peroxidation inhibition activity of argenteane, a natural dilignan isolated from Wild nutmeg, and 3,3'-dirriethoxy-1,1'-biphenyl-2,2'-diol, which represents the central part of argenteane responsible for its antioxidant activity. Although both compounds have the same capacity to scavenge free radicals, argenteane is a more active inhibitor of lipid peroxidation. We show that both compounds penetrate into DOPc and PLPC lipid bilayers and adopt similar positions and orientations, which therefore does not explain the difference in their lipid peroxidation inhibition activity: However, free energy profiles indicate that argenteane has a significantly higher affinity to the lipi

Název v anglickém jazyce

Lipid Bilayer Membrane Affinity Rationalizes Inhibition of Lipid Peroxidation by a Natural Lignan Antioxidant

Popis výsledku anglicky

Lipid peroxidation is a degenerative oxidative process that modifies the structure of membranes, influencing their :biological functions.,Lignans, natural polyphenolic antioxidants widely distributed in plants, can prevent this membrane damage by free radical scavenging. Here,: we rationalize the difference in lipid peroxidation inhibition activity of argenteane, a natural dilignan isolated from Wild nutmeg, and 3,3'-dirriethoxy-1,1'-biphenyl-2,2'-diol, which represents the central part of argenteane responsible for its antioxidant activity. Although both compounds have the same capacity to scavenge free radicals, argenteane is a more active inhibitor of lipid peroxidation. We show that both compounds penetrate into DOPc and PLPC lipid bilayers and adopt similar positions and orientations, which therefore does not explain the difference in their lipid peroxidation inhibition activity: However, free energy profiles indicate that argenteane has a significantly higher affinity to the lipi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Physical Chemistry B

ISSN

1520-6106

e-ISSN

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Svazek periodika

117

Číslo periodika v rámci svazku

17

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

5043-5049

Kód UT WoS článku

000318536700033

EID výsledku v databázi Scopus

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