Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147803" target="_blank" >RIV/61989592:15310/13:33147803 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0734975012000079" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0734975012000079</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biotechadv.2012.01.005" target="_blank" >10.1016/j.biotechadv.2012.01.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids

Popis výsledku v původním jazyce

Ergot alkaloids produced by the fungus Claviceps parasitizing on cereals, include three major groups: clavine alkaloids, D-lysergic acid and its derivatives and ergopeptines. These alkaloids are important substances for the pharmatech industry, where they are used for production of anti-migraine drugs, uterotonics, prolactin inhibitors, anti-Parkinson agents, etc. Production of ergot alkaloids is based either on traditional field cultivation of ergot-infected rye or on submerged cultures of the fungus in industrial fermentation plants. In 2010, the total production of these alkaloids in the world was about 20,000 kg, of which field cultivation contributed about 50%. This review covers the recent advances in understanding of the genetics and regulationof biosynthesis of ergot alkaloids, focusing on possible applications of the new knowledge to improve the production yield.

Název v anglickém jazyce

Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids

Popis výsledku anglicky

Ergot alkaloids produced by the fungus Claviceps parasitizing on cereals, include three major groups: clavine alkaloids, D-lysergic acid and its derivatives and ergopeptines. These alkaloids are important substances for the pharmatech industry, where they are used for production of anti-migraine drugs, uterotonics, prolactin inhibitors, anti-Parkinson agents, etc. Production of ergot alkaloids is based either on traditional field cultivation of ergot-infected rye or on submerged cultures of the fungus in industrial fermentation plants. In 2010, the total production of these alkaloids in the world was about 20,000 kg, of which field cultivation contributed about 50%. This review covers the recent advances in understanding of the genetics and regulationof biosynthesis of ergot alkaloids, focusing on possible applications of the new knowledge to improve the production yield.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biotechnology Advances

ISSN

0734-9750

e-ISSN

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Svazek periodika

31

Číslo periodika v rámci svazku

1 - SI

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

79-89

Kód UT WoS článku

000315761200008

EID výsledku v databázi Scopus

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