CZE Separation of New Drugs for Treatment of Leukemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33151330" target="_blank" >RIV/61989592:15310/14:33151330 - isvavai.cz</a>

Výsledek na webu

<a href="http://download.springer.com/static/pdf/655/art%253A10.1007%252Fs10337-014-2730-9.pdf?auth66=1421833078_4c4cce957f3fc2e08cce9055fec255b6&ext=.pdf" target="_blank" >http://download.springer.com/static/pdf/655/art%253A10.1007%252Fs10337-014-2730-9.pdf?auth66=1421833078_4c4cce957f3fc2e08cce9055fec255b6&ext=.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10337-014-2730-9" target="_blank" >10.1007/s10337-014-2730-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

CZE Separation of New Drugs for Treatment of Leukemia

Popis výsledku v původním jazyce

Imatinib, bosutinib, dasatinib, pazopanib, erlotinib, canertinib and vatalanib are new developed anticancer drugs, especially for treatment of leukemia. In this article, a fast and high throughput capillary zone electrophoresis method has been developedand validated for analysis of these new drugs in pharmaceutical formulas. The method can be easily utilized for determination of all the drugs in one run what is advantageous for the quality control in pharmaceutical industry because there is no need forchanging and optimization of separation conditions when changing the analyte. The separation was performed using an uncoated fused silica capillary with 100 mmol L-1 sodium phosphate buffer pH 2.75, voltage of 25 kV, hydrodynamic injection time of 5 s by 50 mbar, and detection at 214 nm. Under these conditions, the analysis took about 8 min. The validation of all the drugs resulted in recoveries in the range of 84-100 %. The method showed to be precise for all the drugs with RSDs of mig

Název v anglickém jazyce

CZE Separation of New Drugs for Treatment of Leukemia

Popis výsledku anglicky

Imatinib, bosutinib, dasatinib, pazopanib, erlotinib, canertinib and vatalanib are new developed anticancer drugs, especially for treatment of leukemia. In this article, a fast and high throughput capillary zone electrophoresis method has been developedand validated for analysis of these new drugs in pharmaceutical formulas. The method can be easily utilized for determination of all the drugs in one run what is advantageous for the quality control in pharmaceutical industry because there is no need forchanging and optimization of separation conditions when changing the analyte. The separation was performed using an uncoated fused silica capillary with 100 mmol L-1 sodium phosphate buffer pH 2.75, voltage of 25 kV, hydrodynamic injection time of 5 s by 50 mbar, and detection at 214 nm. Under these conditions, the analysis took about 8 min. The validation of all the drugs resulted in recoveries in the range of 84-100 %. The method showed to be precise for all the drugs with RSDs of mig

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chromatographia

ISSN

0009-5893

e-ISSN

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Svazek periodika

77

Číslo periodika v rámci svazku

21-22

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

1477-1482

Kód UT WoS článku

000345004800009

EID výsledku v databázi Scopus

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