Synthesis, Characterization and in Vitro Antitumor Activity of Platinum(II) Oxalato Complexes Involving 7-Azaindole Derivatives as Coligands

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33152618" target="_blank" >RIV/61989592:15310/14:33152618 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.mdpi.com/1420-3049/19/8/10832/htm" target="_blank" >http://www.mdpi.com/1420-3049/19/8/10832/htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/molecules190810832" target="_blank" >10.3390/molecules190810832</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis, Characterization and in Vitro Antitumor Activity of Platinum(II) Oxalato Complexes Involving 7-Azaindole Derivatives as Coligands

Popis výsledku v původním jazyce

The platinum(II) oxalato complexes [Pt(ox)(naza)(2)] (1-3) were synthesized and characterized by elemental analysis (C, H, N), multinuclear NMR spectroscopy (H-1, C-13, N-15, Pt-195) and electrospray ionization mass spectrometry (ESI-MS); naza = 4-chloro-7-azaindole (4Claza; 1), 3-bromo-7-azaindole (3Braza; 2) or 4-bromo-7-azaindole (4Braza; 3). The prepared substances were screened for their in vitro antitumor activity on the osteosarcoma (HOS) and breast adenocarcinoma (MCF7) human cancer cell lines,where 2 showed moderate antitumor effect (IC50 = 27.5 uM, and 18.3 uM, respectively). The complex 2 was further tested on a panel of six others human cancer cell lines, including the malignant melanoma (G361), cervix carcinoma (HeLa), ovarian carcinoma (A2780), cisplatin-resistant ovarian carcinoma (A2780R), lung carcinoma (A549) and prostate adenocarcinoma (LNCaP). This substance was found to be moderate antitumor effective against G361 (IC50 = 17.3 uM), HeLa (IC50 = 31.8 uM) and A2780

Název v anglickém jazyce

Synthesis, Characterization and in Vitro Antitumor Activity of Platinum(II) Oxalato Complexes Involving 7-Azaindole Derivatives as Coligands

Popis výsledku anglicky

The platinum(II) oxalato complexes [Pt(ox)(naza)(2)] (1-3) were synthesized and characterized by elemental analysis (C, H, N), multinuclear NMR spectroscopy (H-1, C-13, N-15, Pt-195) and electrospray ionization mass spectrometry (ESI-MS); naza = 4-chloro-7-azaindole (4Claza; 1), 3-bromo-7-azaindole (3Braza; 2) or 4-bromo-7-azaindole (4Braza; 3). The prepared substances were screened for their in vitro antitumor activity on the osteosarcoma (HOS) and breast adenocarcinoma (MCF7) human cancer cell lines,where 2 showed moderate antitumor effect (IC50 = 27.5 uM, and 18.3 uM, respectively). The complex 2 was further tested on a panel of six others human cancer cell lines, including the malignant melanoma (G361), cervix carcinoma (HeLa), ovarian carcinoma (A2780), cisplatin-resistant ovarian carcinoma (A2780R), lung carcinoma (A549) and prostate adenocarcinoma (LNCaP). This substance was found to be moderate antitumor effective against G361 (IC50 = 17.3 uM), HeLa (IC50 = 31.8 uM) and A2780

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecules

ISSN

1420-3049

e-ISSN

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Svazek periodika

19

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

13

Strana od-do

10832-10844

Kód UT WoS článku

000341502600008

EID výsledku v databázi Scopus

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