Potentiating Effect of UVA Irradiation on Anticancer Activity of Carboplatin Derivatives Involving 7-Azaindoles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156212" target="_blank" >RIV/61989592:15310/15:33156212 - isvavai.cz</a>

Výsledek na webu

<a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123595" target="_blank" >http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123595</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0123595" target="_blank" >10.1371/journal.pone.0123595</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Potentiating Effect of UVA Irradiation on Anticancer Activity of Carboplatin Derivatives Involving 7-Azaindoles

Popis výsledku v původním jazyce

The moderate-to-high in vitro cytotoxicity against ovarian A2780 (IC50 = 4.7-14.4 mu M), prostate LNCaP (IC50 = 18.7-30.8 mu M) and prostate PC-3 (IC50 = 17.6-42.3 mu M) human cancer cell lines of the platinum(II) cyclobutane-1,1'-dicarboxylato complexes[Pt(cbdc)(naza)2] (1-6; cbdc = cyclobutane-1,1'-dicarboxylate(2-); naza = halogeno-substituted 7-azaindoles), derived from the anticancer metallodrug carboplatin, are reported. The complexes containing the chloro-and bromo-substituted 7-azaindoles (1, 2, and 4-6) showed a significantly higher (p < 0.05) cytotoxicity against A2780 cell line as compared to cisplatin used as a reference drug. Addition of the non-toxic concentration (5.0 mu M) of L-buthionine sulfoximine (L-BSO, an effective inhibitor of.-glutamylcysteine synthase) markedly increases the in vitro cytotoxicity of the selected complex 3 against A2780 cancer cell line by a factor of about 4.4. The cytotoxicity against A2780 and LNCaP cells, as well as the DNA platination, wer

Název v anglickém jazyce

Potentiating Effect of UVA Irradiation on Anticancer Activity of Carboplatin Derivatives Involving 7-Azaindoles

Popis výsledku anglicky

The moderate-to-high in vitro cytotoxicity against ovarian A2780 (IC50 = 4.7-14.4 mu M), prostate LNCaP (IC50 = 18.7-30.8 mu M) and prostate PC-3 (IC50 = 17.6-42.3 mu M) human cancer cell lines of the platinum(II) cyclobutane-1,1'-dicarboxylato complexes[Pt(cbdc)(naza)2] (1-6; cbdc = cyclobutane-1,1'-dicarboxylate(2-); naza = halogeno-substituted 7-azaindoles), derived from the anticancer metallodrug carboplatin, are reported. The complexes containing the chloro-and bromo-substituted 7-azaindoles (1, 2, and 4-6) showed a significantly higher (p < 0.05) cytotoxicity against A2780 cell line as compared to cisplatin used as a reference drug. Addition of the non-toxic concentration (5.0 mu M) of L-buthionine sulfoximine (L-BSO, an effective inhibitor of.-glutamylcysteine synthase) markedly increases the in vitro cytotoxicity of the selected complex 3 against A2780 cancer cell line by a factor of about 4.4. The cytotoxicity against A2780 and LNCaP cells, as well as the DNA platination, wer

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS One

ISSN

1932-6203

e-ISSN

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Svazek periodika

10

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

20

Strana od-do

"e0123595-1"-"e0123595-20"

Kód UT WoS článku

000353015800106

EID výsledku v databázi Scopus

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