Synthesis, X-ray crystal structure and biological evaluation of zinc(II)-dichlorido complexes with 9-deazahypoxathine derivatives

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156165" target="_blank" >RIV/61989592:15310/15:33156165 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0020169315002388" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0020169315002388</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ica.2015.05.013" target="_blank" >10.1016/j.ica.2015.05.013</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis, X-ray crystal structure and biological evaluation of zinc(II)-dichlorido complexes with 9-deazahypoxathine derivatives

Popis výsledku v původním jazyce

A series of mononuclear zinc(II)-dichlorido complexes of the general formula [Zn(Ln)(2)Cl2].Solv (1-5); n = 1-5, Solv = CH3CN for 1, 2CH(3)CN for 1b, 1/2H2O for complexes 2 and 4; containing 9-deazahypoxanthine derivatives (Ln, 6-(omega-alkyl) oxy-9-deazapurine derivatives) was prepared and thoroughly characterized (by elemental analysis, ESI+ mass spectrometry, FT-IR and multinuclear NMR spectroscopy, and TG/DTA analysis). Single crystal X-ray analysis of [Zn(L1)(2)Cl2].2CH(3)CN (1b) revealed a distorted tetrahedral geometry in the vicinity of the zinc(II) atom with two 6-ethoxy-9-deazapurine molecules (L1) coordinated through the N3 atoms. The complexes were screened for their in vitro antitumor activity against three human cancer cell lines, PC3 andLNCaP (prostate carcinoma), and A2780 (ovarian carcinoma). Moreover, the ability of the complexes to modulate the secretion of interleukin IL-1 beta and matrix metalloproteinase MMP-2 activity on a lipopolysaccharide (LPS)-activated macr

Název v anglickém jazyce

Synthesis, X-ray crystal structure and biological evaluation of zinc(II)-dichlorido complexes with 9-deazahypoxathine derivatives

Popis výsledku anglicky

A series of mononuclear zinc(II)-dichlorido complexes of the general formula [Zn(Ln)(2)Cl2].Solv (1-5); n = 1-5, Solv = CH3CN for 1, 2CH(3)CN for 1b, 1/2H2O for complexes 2 and 4; containing 9-deazahypoxanthine derivatives (Ln, 6-(omega-alkyl) oxy-9-deazapurine derivatives) was prepared and thoroughly characterized (by elemental analysis, ESI+ mass spectrometry, FT-IR and multinuclear NMR spectroscopy, and TG/DTA analysis). Single crystal X-ray analysis of [Zn(L1)(2)Cl2].2CH(3)CN (1b) revealed a distorted tetrahedral geometry in the vicinity of the zinc(II) atom with two 6-ethoxy-9-deazapurine molecules (L1) coordinated through the N3 atoms. The complexes were screened for their in vitro antitumor activity against three human cancer cell lines, PC3 andLNCaP (prostate carcinoma), and A2780 (ovarian carcinoma). Moreover, the ability of the complexes to modulate the secretion of interleukin IL-1 beta and matrix metalloproteinase MMP-2 activity on a lipopolysaccharide (LPS)-activated macr

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Inorganica Chimica Acta

ISSN

0020-1693

e-ISSN

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Svazek periodika

434

Číslo periodika v rámci svazku

AUG

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

67-73

Kód UT WoS článku

000358299700010

EID výsledku v databázi Scopus

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