Ultra-Performance Liquid Chromatography/Mass Spectrometry Study of Metabolism of 5-Methylpyranopelargonidin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156314" target="_blank" >RIV/61989592:15310/15:33156314 - isvavai.cz</a>

Výsledek na webu

<a href="http://link.springer.com/article/10.1007%2Fs10337-014-2832-4" target="_blank" >http://link.springer.com/article/10.1007%2Fs10337-014-2832-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10337-014-2832-4" target="_blank" >10.1007/s10337-014-2832-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Ultra-Performance Liquid Chromatography/Mass Spectrometry Study of Metabolism of 5-Methylpyranopelargonidin

Popis výsledku v původním jazyce

Anthocyanin dyes represent an important group of plant polyphenols significantly affecting human diet. Their stability in solution is low and it depends on pH, presence of sulfur dioxide and other parameters. Many stable pyranoanthocyanins are formed bycondensation of anthocyanins with small reactive compounds, i.e. pyruvic acid, acetaldehyde, acetone and others, commonly during maturation of food products (e.g. wines and juices). To date, little is known about their metabolism. This communication deals with the study of in vitro metabolism of 5-methylpyranopelargonidin (5-MePPl) as a simple member of the pyranoanthocyanin family and its direct comparison with common flavonoids quercetin and pelargonidin. Human colon adenocarcinoma cells LS174T and human hepatocellular carcinoma cells HepG2 were used for experiments. Metabolites were analyzed by UPLC/MS/MS. Quercetin underwent extensive biotransformation with a metabolic profile typical for flavonoids, corroborating that the used cell

Název v anglickém jazyce

Ultra-Performance Liquid Chromatography/Mass Spectrometry Study of Metabolism of 5-Methylpyranopelargonidin

Popis výsledku anglicky

Anthocyanin dyes represent an important group of plant polyphenols significantly affecting human diet. Their stability in solution is low and it depends on pH, presence of sulfur dioxide and other parameters. Many stable pyranoanthocyanins are formed bycondensation of anthocyanins with small reactive compounds, i.e. pyruvic acid, acetaldehyde, acetone and others, commonly during maturation of food products (e.g. wines and juices). To date, little is known about their metabolism. This communication deals with the study of in vitro metabolism of 5-methylpyranopelargonidin (5-MePPl) as a simple member of the pyranoanthocyanin family and its direct comparison with common flavonoids quercetin and pelargonidin. Human colon adenocarcinoma cells LS174T and human hepatocellular carcinoma cells HepG2 were used for experiments. Metabolites were analyzed by UPLC/MS/MS. Quercetin underwent extensive biotransformation with a metabolic profile typical for flavonoids, corroborating that the used cell

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chromatographia

ISSN

0009-5893

e-ISSN

—

Svazek periodika

78

Číslo periodika v rámci svazku

3-4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

13

Strana od-do

189-201

Kód UT WoS článku

000348976900005

EID výsledku v databázi Scopus

—